Հոդվածը պարունակում է.1 What is HGH or Human Growth Hormone - Somatropin?
2 Types and forms of HGH
3 The effect of HGH on metabolism
4 HGH interaction with other hormones
5 HGH interaction with neurotransmitters
6 Effect of vitamins and amino acids on HGH
7 Effect of Amino Acids on the HGH System
8 Physiological stimulators of HGH secretion
9 Using HGH in bodybuilding and increase human height
10 The use of HGH in medicine
11 The use of somatotropin in sports practice
12 Human Growth Hormone and cancer?
13 Prospects for the development of HGH
To date, Human Growth Hormone (HGH) is the most popular and effective anabolic drug. HGH has found its application not only as the best pharmaceutical preparation for bodybuilding, bodybuilders for muscle mass, muscular development, but also in other sports like boxing, football, basketball and other game sports and athletics
HGH performed well for improving athletic performance - such as increasing endurance, treating injuries. The scope of HGH is growing every day, with the right approach with the use of somatropin (HGH) it is possible to improve athlete athletic performance, strength, physical performance, endurance and shorten the recovery period
Why does our body need HGH so much? C translation of Latin "Soma" means body. Somatotropic means identity to the body and the true body of the origin. During human growth, HGH is the main hormone growth hormone responsible for the growth and structure of the human body, the content and production directly depends on growth, size, weight, the more growth hormone in the growing body, the more a person will grow.
After ossification of the cartilaginous zones of the skeleton, for some time the bones continue to grow in thickness, but the areas like the lower jaw, nose, feet, hands, etc. are not subjected to ossification throughout the life of the person
In rare cases in the young body, the secretion of HGH for various reasons is greatly increased, then there is a case when children grow to huge sizes and even gigantic more than 2 meters. Currently, under the supervision of a specialist in analysis of the content of growth hormone, correction can be carried out, for children suffering from a deficiency of low-growth self-growth, to increase growth hormone in crashes or, alternatively, to artificially slow down the production of somatotropin
For an adult with a fully formed body, HGH performs anabolic functions and is responsible for the processes of protein synthesis in all organs and tissues. Moreover, HGH is a stress hormone, in stressful situations the HGH level rises sharply which helps the body to accelerate protein synthesis in particular in the energy structures of human cells
People with good musculature and a strong constitution are generally more resistant to stress and merit in this HGH
At deficiency of growth hormone in the body of the child, children grow very small, even a pair of diminutive size. With a lack of HGH an adult may begin to develop all sorts of degeneration, or even the state may end in death
A little about the pituitary gland - the pituitary gland is the lower cerebral appendage of the shape and size of the cherry, is located at the base of the skull and is responsible for the production of somatotropic hormones and others, like thyroid-stimulating hormone (affecting the thyroid gland), adrenocorticotropic (activates the adrenal glands), gonadotropic (activates the gonads) , and etc.
The pituitary gland is directly regulated by the hypothalamus, it produces liberins and statins. It is worth paying attention that hgh depends on two hormones - somatoliberin and somatostatin, somatoliberin hypothalamus increases the production of growth hormone by the pituitary gland
Somatostatin, on the contrary, slows the secretion of growth hormone, eventually if we want to increase the amount of growth hormone it is necessary either to increase the amount of somatoliberin or to reduce the content of somastatin
HGH can only affect cells in a test tube at concentrations 2000 times higher than physiological. In a normal body, HGH acts solely on the liver. The liver produces an insulin-like growth factor, which is also called somatomedin. Somatomedin - also has an anabolic and growth effect, affecting the target cells.
As a clinician, I often see cases when after a severe liver disease the child stops growing and a condition similar to pituitary nanism occurs, although the disease as such is caused by a lack of somatomedine.
On the other hand, acromegaly is common with normal levels of blood glucose in the blood. The disease in this case is caused by an excessive level in the blood of somatomedine.
In general, the chain of regulation of anabolism with somatotropic hormone applied to skeletal muscles is as follows:
For anabolic action, for example, for muscle growth, we can use several methods:
1) the most simple and effective is a regular introduction to the body of HGH
2) Increase the amount of somatoliberin in the
3) Reduce the amount of somatostatin
4) To introduce into the body somatomedin
In more detail, consider somatotropin regulation and somatotropin
HGH mainly peptide hormone, consists of a sufficient number of amino acids 191 compounds. In 1921, the action of growth hormone was applied to animals, the effect was artificial gigantism when it introduced a crude extract of the anterior lobe of the pituitary gland. This esperiment of physiologists directly demonstrated the possibility of increasing the growth of a young organism.
In 1944, purified HGH was isolated from the animal, human somatropin began to be isolated from 1956 and started to be used for the successful treatment of dwarfs, later the scientists identified 3 forms of HGH with different molecular weights
A curious fact of the use of growth hormone found its application in basketball, growth hormone began to be used for artificial cultivation of seated basketball more than 2 meters
The release of growth hormone occurs palpably with peaks during the day from 6-12 peaks, usually the majority occurs during physical exertion, extreme situations, temperature changes and during sleep, when high-carbohydrate food is taken, the secretion of HGH decreases
Further studies of growth hormone showed that the growth hormone of lower species does not completely affect the higher species. For example, human growth hormone responds well to monkeys and other mammals, when on the contrary the HGH monkey or cow does not affect the human body at all
For a long time HGH have received and are still receiving from the dead bodies of people, in some countries even special laws have been passed according to which after the opening of the person the pituitary gland is obligatory transferred to special centers for processing. Now HGH have learned to synthesize and receive artificially
In 1963, for the first time, the United States established a national program for the collection of pituitary body corpses with the subsequent manufacture of the drug - human growth hormone
In 1964 in Baltimore began a voluntary organization "the growth of a person" for the help and free treatment of dwarfs suffering from somatropin deficiency, but very soon some of the healthy people of low growth zainetrisovalsya human mountainous growth of low parents wanting to increase the growth of their children, thereby striking a huge interest a promising drug
The popularity of human growth hormone gradually began to gain popularity, parents began to buy their children's HGH to make their parents weeks higher, their human growth hormone as well proved itself in the treatment of severe diseases such as burns, bone fractures, stomach ulcers, in the future, growth hormone will find its application for a more extensive list of preexisting and treatment of diseases
Also, growth hormone found its application in sports, thus increasing demand, which could not but affect the price of growth hormone in the market by increasing it
The popularity of growth hormone in the world is gaining popularity with every passing day and has great prospects for application and development, so the high popularity of human growth hormone deserved thanks to effective action without side effects
To date, the world's largest pharmaceutical company recognized as the world's largest market for medicines Pfizer, producing the best growth hormone under the brand Genotropin, the only drawback of this drug is the relatively high cost
The international unit of HGH 0.9 mg is 3 IU or 1 IU is 0.3 mg, the average dosage for men is 0.9 mg or 3 IU when there is enough 0.6 or 2 IU for women, for anabolic effect and faster growth muscles can increase the dosage to 2-3 IU
As studies have shown the use of growth hormone in the morning on an empty stomach and before bedtime has the same effect, the patient can choose from a lifestyle and convenience. Also, studies have shown that dividing the daily dosage into 2 parts has the same effect as taking a full daily dosage in one dose
HGH is administered subcutaneously for convenience in the fold of the abdomen 2-3 mm, but in fact it can be injected into any part of the body, shoulder, leg, but the stomach is the most comfortable and painless, some drive HGH into problem areas, considering that the place where the drug was led will be burn fat faster, it is not, absolutely the same effect is achieved from conducting any part of the body
The average course of treatment, recovery is 5-8 months, more than 8 months HGH becomes less effective and it is necessary to finish the course or pause
The dosage for women and the course of treatment is less than for men, because HGH acts on women better and more effectively, due to many factors, interaction with other hormones, better absorption, weight, muscle tissue ratio, etc.
Female gepophysis produces more growth hormone than the male body, in addition to all women are more sensitive to growth hormone that allows women to drive a smaller dosage with the same good success
Perhaps the most important action that growth hormone has is protein synthesis, at the beginning of the liver, blood and muscles. HGH causes an anabolic effect as a potent steroid, growth hormone increases the penetration and transport of amino acids to the muscles, with proper physical exertion in the gym, muscle fibers grow and thicken, causing a significant increase in muscle mass
Growth hormone can be divided into 2 peptide parts, the first part has an anabolic effect, the second fat burning effect, on the whole, there is an increase in immunity and general improvements in the body's performance. Acceleration of protein synthesis with the growth effect of HGH, its ability to accelerate the growth of bones in length, to the closure of the cartilaginous zones, and also the growth of bones in thickness after the cartilage zones are closed
In the management of small and medium doses, growth hormone increases the permeability of cells to glucose and exerts an effect similar to insulin. The synthesis of protein increases in the pancreas, thereby causing an increase in insulin production. When conducting high and super high doses of growth hormone, an increase in blood sugar occurs, a possible dystrophy of the pancreas reduces the production of insulin, that is, in excess of large doses of growth hormone can cause diabetes mellitus
Reduction of adipose tissue, hormone treatment of obesity growth has shown an excellent effect under the condition of physical and cardio training, leads to simultaneous fat burning muscle growth
Growth hormone improves the quality of blood that speaks about the improvement of protein-synthetic processes in the bone marrow
Mineral metabolism - at the beginning of treatment with growth hormone, a delay in the excretion of phosphorus and potassium in the urine occurs, which is an indicator of protein synthesis
Calcium and its content increase, then a decrease is observed, this in turn indicates the formation of a new new and strengthening of the old bone tissue. An indicator of muscle growth in the body is observed in the retention of phosphorus in the body, in addition to the anabolic effect of growth hormone is a powerful anti-catabolic. Anyone who begins to introduce a STG in order to cause an anabolic state immediately notice a drop in appetite.
For many, this is puzzling, since the growth of muscle mass in their understanding should be associated with an increase in appetite, but not vice versa. Recent studies have shown that the anti-catabolic effect of growth hormone can exceed its direct anabolic effect.
Therefore, according to the logic of things, the consumption of plastic material should not increase, but decrease.
When the thyroid function decreases, the body reacts very poorly to the introduction of HGH from the outside. In this case, to achieve a better therapeutic effect, it is necessary to first correct the function of the thyroid gland (in the direction of its increase). This is achieved by administering thyroid hormones (they are not addictive) and some other (adrenomimetic) drugs.
It is significant that in patients with hyperthyroidism (increased thyroid function) the level of HGH in the blood is always elevated. The effectiveness of the introduction of HGH in summer is always higher than in winter, because in the summer, there is a slight physiological increase in thyroid function. Plays a role and increase the sensitivity of tissues to thyroid hormones.
Most often, thyroidin is used, obtained from dried thyroid glands of cattle. More rarely, its synthetic analogues, such as triiodothyronine (triiodothyronine hydrochloride) and L-thyroxine. Combination preparations containing combinations of L-thyroxine with triiodothyronine are also available.
The most common ones are tireocomb, thyrotomy, and cythel.
Small doses of adrenal cortex hormones (glucocorticoids) enhance the effect of growth hormone on tissue. Large doses, on the contrary, weaken. Moreover, certain doses of glucocorticoid hormones can completely block both the growth and anabolic effects of somatotropin. Some forms of pituitary nanism (dwarfism) are not related to the fact that there is little somatotropin in the body and not to the fact that the liver does not produce enough somatomedin.
And that, and the other can be quite enough. Excess glucocorticoid adrenal glands due to ACTH hypersecretion by the pituitary gland is to blame.
Glucocorticoids block the effects of somatomedin and somatotropin at the cellular level, plus, in addition, they decrease the secretion of GH by eosinophilic cells of the pituitary gland.
Glucocorticoids not only block the effects of somatotropin. After their introduction into the body as a whole in a dose of 100 mg, they prevent the release of GH in response to insulin hypoglycemia and intravenous infusion of arginine, the post-training release of GH while taking L-DOPA also decreases.
Approximately the same can be said about all other methods of stimulating the synthesis and release into the blood of GH and somatomedin, as well as their final effects.
Glucocorticoids do not simply block the effects of GH. They themselves are also catabolics. Post-training release of somatotropin into the blood is also blocked.
Growth hormone secretion by night also suffers from glucocorticoids. The peaks of the release of growth hormone become smaller in height and less frequently in time.
Glucocorticoids have a negative effect not only on the somatotropin system, but also on the synthesis system and the final effects of other hormones that are synergistic (enhancers) of the somatotropin system.
Testosterone enhances the system of somatotropin in men and glucocorticoids, possessing antagonism to testosterone is no longer directly but indirectly showing its antagonistic effect to the system of somatotropin.
When hyperfunction of the adrenal cortex to enhance the action of growth hormone, it is adjusted downwards. When hypofunction of the adrenal cortex increases its work, or inject small doses of glucocorticoid drugs into the body. Currently, only synthetic glucocorticoids are used, and their choice is quite wide.
These are mainly prednisolone, prednisolone hemisuccinate, methylprednisolone, dexamethasone, triamcinolone, hydrocortisone, hydrocortisone acetate, hydrocortisone hemisuccinate. Apply all these drugs carefully and in very small doses so as not to cause a catabolic effect.
Hyperfunction of the adrenal cortex is most common in Itsenko-Cushing's disease, when hyperplasia of the adrenal cortex passes through the hyperproduction of ACTH and the level of glucocorticoids in the blood exceeds all imaginable and inconceivable limits. It is possible to diagnose Itsenko-Cushing's disease only by the sight of the patient.
The fact is that the deposition of fat on the body of such people is very characteristic. Fat is deposited mainly on the cheeks, abdomen, sides and buttocks. The muscles of the arms and legs are atrophied, and against the background of a large abdomen and buttocks, they optically look even thinner than they really are. The contours of such a person’s body resemble a pear. The deposition of fat is in the above places due to the fact that there is the maximum number of insulin receptors.
Insulin compensates for the catabolic effect of glucocorticoids in relation to protein metabolism, but at the same time, it supercompensates the catabolic effect of steroids in relation to fat metabolism.
Excess glucocorticoids in the body can occur not only during illness. Hypertrophy of the adrenal glands can develop for a variety of reasons. It can develop after pregnancy, after often repeated stress, against the background of a chronic inflammatory disease (usually lungs or tonsils), after all, simply due to age-related reasons. None of the stress in a person's life passes without a trace the adrenal glands at least a little, but they are hypertrophied. By the second half of life, many people begin to resemble a pear in their outlines of their bodies. This is called Itsenko-Cushing's age syndrome.
Before starting growth hormone therapy, the glucocorticoid content in the blood should be lowered regardless of whether it is Cushing disease, or cushingoid syndrome of any origin.
Severe forms of Itsenko-Cushing disease are treated radically.
One of the adrenal glands is removed, and the other is irradiated with a neutron beam. The disease takes off like a hand. Mild disease, as well as cushingoid syndromes, are treated conservatively. Prescribe drugs that reduce the function of the adrenal cortex.
The leader in this case is such a drug as Aminoglutethimide (syn. "Orimeten"). Aminoglutethimide is good because in addition to suppressing the adrenal cortex, it reduces the synthesis of estrogen in the body and thus has an indirect androgenic effect.
The indirect androgenic effect is also due to the fact that glucocorticoids suppress the activity of androgens both at the cellular and systemic levels. Eliminating excess glucocorticoids, aminoglutethimide inhibits the action of androgens.
Form release: tablets of 0.25 g.
Is ingested 0.25 g, 2-4 times a day.
Side effects are extremely rare and manifest only in the form of allergies, which quickly passes with the abolition of the drug.
In addition, aminoglutethimide has anticonvulsant activity.
Chloditan (syn. "Mitotane") is another highly active drug that suppresses the activity of the cortical region of the adrenal glands.
Form release: tablets of 0.05 g.
Are taken orally, starting with 2-3 g per day in the first 2 days, and then at the rate of 0.1 g / kg body weight per day. The daily dose is given in 3 doses in 15-20 minutes after eating. Side effects are more common than while taking aminoglutethimide.
Nausea, loss of appetite, headache, drowsiness. When they occur, the dose is simply reduced to the level at which the drug is well tolerated.
Both aminoglutethimide and chloditan are classic anti-catabolic agents. Sometimes they are even used as a therapy for building muscle.
Currently, in the pharmaceutical market of our country there are mainly 2 types of short-acting insulin: human (genetically engineered, obtained by bacterial synthesis) and porcine (obtained from the pancreatic glands of pigs in meat-processing plants). Less common is the third species, whale insulin, derived from the pancreas of blue whales.
Pork insulin, although much cheaper than human insulin, is not inferior in quality to it and can be used with exactly the same success.
Feature of the action of insulin is that it greatly reduces the sugar content in the blood. The whole difficulty of using an insulin technique is to cause a decrease in blood sugar levels sufficiently strong so that the release of somatotropin is maximum and at the same time not strong enough for a person to lose consciousness.
Insulin begins to be administered very carefully, with small doses (4 U) subcutaneously. If exercise is in the morning, then insulin is injected after exercise. If training is in the evening or in the afternoon, then insulin is introduced in the morning and the athlete starts training only after the insulin action has ended. Every day, the dose of insulin is increased by 4 IU and so on until the dose reaches 60 IU. 60 U is a safe dose at which not a single person has ever lost consciousness.
Unlike other peripheral hormones, insulin does not have tropic regulation. Therefore, the introduction of insulin is not addictive and addictive.
Strangely enough, even many doctors do not know this. In a psychiatric clinic, I had to monitor patients who were treated with insulin comas. Some of them were injected with 240 IU of insulin daily and then abruptly discontinued treatment at once. Nothing happened after that. No withdrawal symptoms, no symptoms in the recoil, and similar unpleasant things.
Even on the contrary, if the blood sugar level was slightly elevated (prediabetes) before insulin treatment, the blood sugar level returned to normal after insulin treatment. If the sugar curve was flat, it assumed a normal appearance, etc. Treatment with insulin not only causes no negative, destructive changes in the pancreas, but on the contrary strengthens the pancreas, and increases its synthetic capabilities (this is a synthesis of its own insulin).
Insulin sensitivity is different for different athletes. With elevated blood sugar levels, some do not feel anything even after administering 20 IU of insulin. Naturally, for them the maximum safe upper limit would be not 60 IU, but 80 IU. With a constitutionally low blood sugar level, the body's sensitivity to insulin, on the contrary, can be very high. The introduction of insulin in such cases has to start not with 4, but with 2 U and increase the dose not daily, but once every 2-3 days. The maximum allowable dosage is no more than 40 U per injection.
There are cases at first glance paradoxical, when, as the course of treatment with insulin proceeds, sensitivity to it does not decrease, but, on the contrary, increases. So, for example, having reached the standard dosage of 60 U, a person suddenly begins after some time to feel that this dose is high because of too much hypoglycemia.
Gradually, reducing the daily injected dose of insulin, he stops at 40 U, as more adequate, but here again a “surprise” awaits him. After some time, these 40 U become too large again and the dose has to be reduced again. Such a reaction to insulin administered from the outside only confirms the postulate that exogenous insulin strengthens its own pancreas and contributes to a greater production of endogenous (own) insulin. Naturally, with this, the need for insulin, administered from the outside, falls.
There are two methods of administering insulin - soft and hard. According to a soft method, insulin is injected after a meal, and hard on an empty stomach. Introducing insulin on an empty stomach can, of course, cause a large release of somatotropin. But such a technique is also more risky because of the great danger of falling into a hypoglycemic coma.
Therefore, using a rigid method, insulin can only be administered by someone who can afford outside observation for at least 1.5-2 hours. 1.5-2 hours after insulin injection, the person is observed and then the food is loaded. Observation is necessary in order to remove a person from a hypoglycemic coma, if he falls into it. The withdrawal from a hypoglycemic coma is carried out using intravenous administration of 40% glucose solution, or subcutaneous injection of 1 ml of 0.1% adrenaline solution. Sometimes they do both together. First, adrenaline, and then, if it does not help, then glucose.
Food loading on the background of the introduction of insulin is a special difficulty. Each type of insulin has two fractions. One faction goes exclusively along the fatty path, and the other - along the fat and protein one at the same time. Since the regulation of insulin substrate action, everything will depend
crystalline amino acids go straight to the muscles. There, as a result of adequate physical exertion, they are immediately included in the protein-synthetic processes. Some of the amino acids initially "converted" into proteins in the liver. Then these proteins are transported to the muscles.
Food loading with amino acids immediately causes three serious problems.
The first problem is that pure crystalline amino acids are needed too much.
The ideal and purely hypothetical option in this case is to feed only with crystalline amino acids and nothing more. It is with such a food load that all insulin will go along the “protein path”, and will give an increase in lean muscle mass without gaining fat. However, the supply of pure crystalline amino acids alone is extremely expensive and, for economic reasons, not very feasible.
In addition, after the introduction of insulin, a positive nitrogen balance will be maintained all these days. The total amount of amino acids in the diet should be increased to 2-3 g per 1 kg of body weight, and sometimes more. It all depends on what goals this athlete has set itself. Recently, there is an increasing amount of scientific evidence that the maximum positive nitrogen balance does not require more than 1.7 g of protein per 1 kg of body weight.
However, the neurotransmitter role of some amino acids, their ability to be included in energy metabolism, the specific-dynamic action of food, etc. are not taken into account here.
The second problem is that pure amino acids very weakly suppress hypoglycemia. For complete relief of hypoglycemia, at least a minimal amount of carbohydrates is needed, but it is only necessary to overdo it, as these carbohydrates instantly direct insulin along the “fatty pathway”. After all, the “path” of insulin is regulated, as we know, mainly by food substrates.
The third problem is that in individuals with atrophic gastritis, or low acidity of the gastric juice, crystalline amino acids cause a laxative effect. With zero acidity - a real diarrhea. It is necessary to experimentally select the amount of crystalline amino acids that an athlete can assimilate without any side effects for himself.
The average food load option is as follows. It is necessary to strive to ensure that about 1/3 of the total dietary intake is crystalline amino acids, or amino acids with peptides, 1/3 part - protein powders, and 1/3 part - protein food. Amino acids with peptides are cheaper than pure amino acids and more palatable (all pure crystalline amino acids have an extremely unpleasant taste and the better the amino acids, the worse they taste).
Protein powders should not be stirred until concentrated. Prepare them to the consistency of mashed potatoes. The most desirable egg protein, because it contains all amino acids and is optimally balanced. Further, according to the degree of usefulness, milk comes from casein, meat, soy and milk whey protein. For faster and more complete digestion of protein, along with it it is necessary to use digestive enzymes.
Under normal conditions, any protein requires several hours for such digestion, and there is no time to wait on the background of insulin. It is necessary to achieve the entry of amino acids into the blood as quickly as possible until the action of insulin has stopped. The most common preparations containing digestive enzymes are pancreatin, festal, enzistan, mezim, trienzyme, etc. My practice shows that the best of these drugs is “festal”.
Ideally, it is necessary to consume at least 100 - 150 g of pure crystalline amino acids within 6 hours of insulin action, and if material resources permit, then even more.
If the material capabilities do not allow using only amino acids and protein for food loading, then you should simply strive simply for a protein diet, reducing carbohydrate intake to a minimum and completely eliminating fat intake.
If insulin is injected on an empty stomach, then the relief of hypoglycemia should be started with taking amino acids, washing them down with a small amount of water. If hypoglycemia is not completely stopped, then you can take some easily digestible carbohydrates and in exactly the same amount that would be enough to stop hypoglycemia. Excess carbohydrates instead of creating glycogen depots will go straight into adipose tissue and this should be remembered. In no case can not be fed up with complex carbohydrates "to the dump".
Nothing but obesity will result. A good illustration of this is the sumo wrestlers, who are gaining a huge fat mass with the help of carbohydrate loading on the background of insulin. For the relief of hypoglycemia, sports dry drinks diluted in water are best suited for carbohydrate (carbohydrate) loading or carbohydrate nutrition at a distance and during exercise.
In individuals with initially high levels of glucocorticoid hormones in the body, the increase in fat mass may exceed the increase in muscle with the slightest error in the food load (overfishing with carbohydrates). In such persons, fat is deposited mainly on the stomach, sides, buttocks and cheeks.
The whole complexity of the food load on the background of insulin lies in the fact that you can not load carbohydrates, the diet should be almost entirely protein.
But one day I came across an amazing case in practice. An athlete who started injecting insulin amid an amino acid load suddenly collapsed and fell until he returned to his usual diet, which included a fair amount of carbohydrates.
It was on such a normal diet that he gained dry muscle mass despite all the conceivable and inconceivable laws of physiology. For any other person, such a diet on the background of insulin would not cause anything but obesity.
The use of insulin for anabolic purposes is so complex and extensive that I dedicated a separate book to it. A new version of this book is soon coming out of print under the title. Anabolism with insulin II See the ad on the last page of the cover.
A lot of discussion and violent debate is the problem of a combination of insulin and growth hormone. After all, in all textbooks on biochemistry there is a separate chapter, which is called “Continsular hormones”.
The official science also considers somatotropin to be a classic contra-insular hormone, but I have already explained the ambiguity and ambiguity of this statement. I repeat once again: small doses of HGH only strengthen the pancreas, without causing any harm to it. Only large doses of somatotropin can cause diabetes mellitus, and only if there is a genetic predisposition to this.
Suppose we already know some genetic predisposition to diabetes, and growth hormone is still needed. What to do? Investigate sugar metabolism, on the subject of hidden or clearly diabetes. This is not very difficult, as there are simple and at the same time reliable laboratory indicators. First, it is necessary to do basic blood and urine tests for sugar. All analyzes are done in the morning on an empty stomach.
The blood of a healthy person on an empty stomach contains 4.4–6.6 mmol / l (80–120 mg%) of glucose. A patient with diabetes mellitus may increase its concentration to 28-44 mmol / l (500-800 mg%) or more.
However, in the initial stages of diabetes or in its milder forms (and we are talking only about such cases), fasting blood sugar does not exceed the norm, and is absent in the urine. Therefore, a simple blood test for sugar is not an absolute indicator of normal carbohydrate metabolism. A much more accurate analysis is the PTH test of tolerance (resistance) to glucose. It is done as follows. The patient first determine the level of sugar in the blood on an empty stomach. After that he is allowed to drink 50 g of glucose, dissolved in 200 ml of water. During the current 3 hours, blood samples are taken from him every 30 minutes. In a healthy person, the sugar content in the blood after such a load of glucose increases during the first hour by about 50% from the initial level, but not more than 9.4 mmol / l (179 mg%), and by the second hour decreases to the initial value or even much lower due to reactive release of insulin by the pancreas with fairly large reserves.
In patients with diabetes mellitus, even in the initial latent stage of the disease, the ascent occurs later and it is larger in size. To the initial level of glucose does not fall even after 3 hours.
Even more accurate is the double load test, in which the second portion of glucose in the amount of 50g is allowed to drink 1 hour after the first portion. In a healthy person, the first load causes an increase in insulin secretion and therefore the second portion of glucose does not lead to a new increase in the amount of sugar in the blood.
With indicators above the norm they speak about the presence of a “hump”. If sugar indicators do not return to normal for a long time, then they talk about a “flat” sugar curve. If repeated glucose intake results in a repeated rise in the level of sugar in the blood, this gives a picture of a double-humped sugar curve.
The level of sugar in the blood may depend on the method of blood collection: in capillary blood the sugar level is higher than in the venous one. Therefore, in this case it is necessary to take blood only from a finger.
A rise in blood sugar is not always a sign of diabetes. It may be the result of ordinary emotional arousal. Strong stress causes a very significant rise in the level of sugar in the blood. This mechanism arose and became entrenched in the process of evolution, since in a stressful situation a person always needs more energy either for an attack or for defense in order to escape, after all.
In the urine, sugar is detected only when its blood level reaches very high levels and the kidneys are unable to cope with filtration. On the other hand, the detection of sugar in the urine with its normal content in the blood may not speak about diabetes, but about the pathology of the kidneys. With some
there are signs of diabetes. In short, the pancreas is stimulated by fatty acids, the content of which in the blood is directly proportional to the fat content in the body.
Due to spontaneous lipolysis, fat at a constant rate breaks down into fatty acids and glycerin, which saturate the blood, and then under pressure of insulin again comes from the blood into adipose tissue, where neutral fat is formed. After the elimination of excess weight, all indicators of blood sugar are normalized. For an objective assessment of sugar metabolism, you must be completely free of adipose tissue.
As a practical doctor, I often had to face an interesting phenomenon in practice.
In individuals with osteochondrosis of the cervical spine, the sugar curve after the load does not rise very high and corresponds to the norm, but then for a long time does not come to the initial level. Turning to the academic literature, I found out that this phenomenon has been known to clinicians for a long time, but its treatment has not been proposed by anyone. By the nature of my work, I often encountered the phenomenon of a flat sugar curve in wrestlers and in boxers. The specificity of these sports is such that osteochondrosis of the cervical spine develops very early. For wrestlers this is due to the performance of the “wrestling bridge”, and for boxers because of the constant blows to the head. Few people know that a blow to the head injures the neck much more than the head itself. Even a slight displacement of the head shifts the vertebrae.
At the same time, the neck vessels that feed the medulla are squeezed. It is in the medulla oblongata that the centers of the sugar balance are located. From here and its infringements in the form of a flat sugar curve. Traction of the cervical spine in combination with a special gymnastics helps to bring the sugar curve back to normal. Surprisingly, the course of treatment with small doses of insulin or some sugar-lowering drugs even more quickly normalizes the sugar curve, even without affecting the cervical spine.
Cervical factor "generally can not be underestimated. Per unit transverse treatment of the cervical spine is experiencing a load much greater than the lumbar.
Therefore, the first minor signs of cervical osteochondrosis appeared in people already from the age of 16. The head turns out to be a very hard thing. In the process of evolution, we have not yet had time to adapt to wearing it. Cervical osteochondrosis as a result of degeneration of intervertebral cartilage develops even in the absence of any harmful external factors. What can we say about the increased load!
If the survey does not reveal overt or latent diabetes, then somatotropin can of course be used. So, we can return to our initial discussion: is it possible to combine insulin with somatotropin, and is it really necessary?
If an athlete prepares systematically on insulin alone and gets exactly the result he is satisfied with, there is no need to connect any other insulin-like anabolic agents to insulin.
If a person uses only growth hormone and has a decent dynamics of its development, there is also nothing to worry about. You can perfectly provide pharmacological support of training with one drug without blocking the refrigerator with cans in bright packages. The same can be said about steroids. If there are enough of them alone, then, thank God, the preparation of some other group will go the next course.
A completely different situation will arise when only a potent drug cannot provide the desired dynamics. Let me give an example: an athlete gets a good and fast increase in muscle mass from insulin alone, but ... one big “but” arises: this increase in muscle mass comes with the same amount of subcutaneous fat.
A man never gained muscles so quickly, he likes insulin, but he never gained fat so quickly, and I don’t want to throw insulin. And here somatotropin comes to the rescue. Small doses of somatotropin help translate insulin from fat to protein. Then the increase in muscle mass will be maximum, and the increase in fat is minimal.
Take another example. A man chose pharmacological accompaniment as a somatotropin because, at the same time as gaining muscle mass, he wants to heal an old spinal injury. Cartilage is 100 times more sensitive to somatotropin, or rather, to somatomedin, and the choice in this case is made correctly. But even here there is one big “but” - somatotropin is very expensive, and a lot of it needs quite a lot for the entire course of treatment, and because of its high cost, it is forged more often than all other drugs. The activity of growth hormone can be increased by combining it with small doses of insulin and thyrocalcitonin.
Neurotransmitters are mediators of nerve signal transmission from one nerve cell to another. Endorphins and catecholamines have the strongest effect on the synthesis and secretion of HGH. Catecholamines are mediators of the transmission of nerve excitation signals in the central nervous system. The main neurotransmitters catecholamines are dopamine, norepinephrine, adrenaline (which is also the hormone of the adrenal medulla). The chain of catecholamine biosynthesis can be simplified as follows:
As you can see, the essential amino acid tyrosine can be synthesized from the essential amino acid phenylalanine. Under the action of the enzyme tyrosinase, L-DOPA (dioxophenylalanine, left-handed) is synthesized. Part of L-DOPA goes to the formation of melanin (this is the same pigment that gives color to the hair, iris, skin, and even some nervous structures), and part to the formation of dopamine, from which norepinephrine and adrenaline are already synthesized.
There is also a feedback between melanin and L-DOPA.
The central nervous system melanin serves as a kind of reserve depot, from which, if necessary, the reserves of L-DOPA will be replenished. Only adrenaline and L-DOPA are produced in pure form. If you need to increase the amount of dopamine or norepinephrine in the body (CNS), this is done indirectly.
There are a- and b-adrenoreceptors of cells. Each catecholamine can act on both one and another type of receptor, depending on the dosages in which it is used.
Stimulation of a-adrenoreceptors leads to increased release of somatotropin by the pituitary gland. Stimulation of b-adrenoreceptorov, on the contrary, inhibits. On the other hand, the blockade of a-adrenergic receptors leads to inhibition of the release of HGH, and the blockade of b-adrenergic receptors increases the secretion of somatotropin.
Adrenaline affects both a-and b-adrenergic receptors, currently it is produced synthetically. Enter it subcutaneously. Medium and high doses of adrenaline stimulate HGH release, because they act more strongly on a-adrenoreceptors than on b-receptors.
Microdose adrenaline affect mainly b-adrenergic receptors. The content of HGH in the blood does not increase, but it does not decrease either. In the "pre-steroidal epoch", athletes, before training, injected themselves subcutaneously with adrenaline, thereby increasing endurance in the process of training and, at the same time, increasing the jet training release of HGH.
The mediation of norepinephrine is indirectly affected. Noradrepalin stimulates a-adrenoreceptors, increasing the release of HGH into the blood and providing
everything else has a clear fat burning effect. The most powerful agent that activates the release into the blood of norepinephrine is ephedrine. This herbal preparation is obtained from ephedra horsetail and used according to a special technique. Available in the form of ephedrine hydrochloride. Another powerful means of stimulating noradrenergic structures is the yohimbine alkaloid.
Get it from the bark of one of the African trees. Available in the form of yohimbine hydrochloride.
Dopamine acts primarily on a-adrenoreceptors. Introduction to the body of drugs dofiminostimuliruyuschee action itself does not lead to an increase in the concentration of HGH in the blood, but the release of HGH in response to physical activity increases, which significantly increases the efficiency of the training process. Curiously, with acromegaly, the administration of drugs that stimulate dopamine synthesis, on the contrary, leads to a decrease in its excessive release.
The most commonly used agents that enhance the synthesis of dopamine in the body are: the plant alkaloid bromocriptine (parlodel), L-DOPA (dioxyphenylalanine - a derivative of the amino acid phenylalanine). Moreover, it turned out that L-DOPA itself plays an important role in the CNS as a neurotransmitter. For the first time, L-DOPA was used by Americans in sports practice. The amino acid phenylalanine, taken in sufficiently large doses, serves as a source of synthesis in the body of L-DOPA, which then turns into dopamine with the entire subsequent chain of transformations (dopamine> noradrenalin> adrenaline). Dofomin can also be synthesized from the amino acid tyrosine.
Tyrosine, like phenylalanine, is widely used in sports and medical practice in many countries.
The practice of applying L-DOPA has perhaps the richest history. This is partly due to the fact that L-DOPA has proven itself in clinical practice in the treatment of many serious diseases. At the beginning, L-DOPA was used in Parkinson's disease and parkinsonian age (senile hand tremor).
Then it turned out that the drug not bad helps to cure a person from the exhaustion of the nervous system, which was caused by some external depleting factors. Ordinary rest here does not help and one cannot do without good medicines. In the Moscow Clinical Specialized Hospital №8 named Z.P. Solovyov there is a clinic of neurosis. Neurosis - a temporary reversible violation of the GNI, which occurs after severe overload. Sometimes neuroses are protracted and difficult to treat. Since the 80s of the twentieth century. The leading specialists of the clinic successfully applied L-DOPA course therapy (0.5 g once a day for 10 days) in case of exhaustion of the nervous system.
According to our observations, L-DOPA gives a very good result in the treatment of male impotence, because increases the sensitivity of cells to sex hormones. A good result was also obtained in the treatment of various forms of nervous depression caused by extreme neuropsychic overloads.
Since the mid-70s, Americans began to use L-DOPA in sports and continue to use it until now. If you take L-DOPA in the morning, it smoothly fits into the daily biorhythms. At the same time, post-training secretion of HGH is significantly increased. It is interesting that only L-DOPA used without training has no effect on the HGH system.
With acromegaly, taking L-DOPA, on the contrary, reduces excessive secretion of growth hormone.
In the US market of sports nutritional supplements is still full of commercial products containing L-DOPA. True, they all have some other name. Some firms have lured themselves to the fact that they produce tablets with L-DOPA under the name of pill growth hormone (!) Or “pill IGF-1” (insulin-like growth factor). In order not to fall for such a cheap hook, you should always analyze the composition of the drug you are offered.
L-DOPA is a good thing, no doubt, but it is far from worth the money paid for HGH and IGF-1. Tablets of HGH and IGF-1 cannot even be in principle, because these are peptides that are instantly digested in the gastrointestinal tract.
It is noteworthy that L-DOPA has an antitumor effect. Since the mid-1980s, there is an official instruction from the Ministry of Health on the use of L-DOPA in oncological practice, which, however, is not being followed, since It is much easier to select a patient by first running the treatment and then intimidating with the upcoming operation.
The disadvantage of the drug is that it is somewhat toxic to the liver.
Worldwide, L-DOPA is available in tablets and capsules of 0.25 and 0.5 g. Personally, as a medical practitioner, I met him only in tablets of 0.5 g.
In case of overdose, nausea and vomiting are possible. It is caused by an excess of dopamine, which is formed from L-DOPA in the body.
Dopamine has the ability to activate the vomiting center, located in the medulla oblongata.
Women are almost 2 times more sensitive to the drug than men, they have a more pronounced therapeutic result, and the dose selection begins with a smaller value. In men, selection of the optimal dose begins with 1 tablet in 0.5, and in women with? tablets, with a dose of 0.25 g
The main amount of drugs containing L-DOPA is now available worldwide for the treatment of Parkinson's disease. In many of them, L-DOPA is combined with substances that block its destruction at the periphery. So more drug gets into the brain.
Yes, and the dose of L-DOPA can be reduced. In a drug like NACOM, L-DOPA is combined with benzerazide. Both carbidopa and benzerazide inhibit the decomposition of L-DOPA in the blood and peripheral tissues. So more goes to the brain. The selection of dosages of these drugs should be done very carefully, starting with? pills, otherwise not to pass nausea and vomiting. This applies to both therapeutic and sports practice. I repeat once again that the increase in HGH release under the action of these drugs will occur only against the background of fairly short, fairly high-intensity workouts (otherwise there will be absolutely no result in such enhancements of HGH release).
In sports medicine, b-adrenoreceptor blockers are widely used. On the one hand, they increase the secretion of HGH, and on the other hand, increase the tone of the parasympathetic nervous system, which is responsible for anabolic processes in the body. The number of b-adrenoreceptor blockers currently used in sports medicine is quite large. First of all, it is anaprilin (obzidan), whiskey (iprindolol), trazikor (oxyprenolol) and many others. Basically, they are used in athletics and in those sports that are associated with the manifestation of great endurance - swimming, rowing, skiing, etc.
This is due to the fact that b-adrenergic receptors accelerate heart rate. B-adrenoreceptor blockers simultaneously increase the strength of contractions of the heart muscle.
Endorphins are a relatively recently open class of neurotransmitters. They are produced by the pituitary gland, have a morphine-like (narcotic and analgesic) effect. Endorphins are currently being produced synthetically. They are hundreds of times better than morphine in their effect.
However, it compares favorably with the latter in that they are not addictive and addictive. In the US, endorphins have been used in clinical and sports practice for more than 20 years. The strongest endorphin is b-endorphin. It was first synthesized in 1975. It is a polypeptide consisting of 31 amino acid residues.
Both morphine and endomorphins cause a significant increase in the level of HGH in the blood. This effect is associated with their effect on the secretion of somatoliberin by the hypothalamus.
In addition, they accelerate the formation of DNA, significantly reduce basal metabolic rate, lower body temperature. A reduction in basal metabolism leads to a significant slowdown in catabolism and, coupled with somatoliberin-stimulating effects, has the strongest anabolic effect and economy of all food substrates.
Morphine cannot be used in sports practice, of course, but b-endorphin deserves close attention. When administered intravenously, b-endorphin can cause an increase in plasma HGH level by a factor of 20-30 (!). No other tool currently has this effect. This drug has a great future.
It is possible to cause an enhancement of the synthesis of b-endorphin by the body itself by means of a metered painful effect (DBE). DBV is caused by acupuncture, a lot of needle bed, Kuznetsov applicators, stretching exercises with pain effect, etc. A very good result is the treatment of certain areas of the body with a spark discharge. The standard therapeutic apparatus for this procedure is the D'Arsonval apparatus. The strength of the spark discharge can be adjusted.
Even in itself, the introduction of nicotinic acid alone lowers blood sugar and increases the sensitivity of tissues to both insulin and somatotropic hormone. Vitamin PP is a versatile vitamin of its kind. The fact is that all without exception, redox reactions in the body flow through enzymes, which include nicotinic acid. These enzymes are called NAD and NADP dependent enzymes.
NAD is a nicotinoamidine nucleotide. NADP - nicotinamide dinucleotide phosphate. Nicotinic acid, therefore, takes, where direct, and where indirect participation in all types of exchange. In small doses, it has a vitamin effect (prevents pellagra), and in large doses (megadoses), it already has a serious pharmacological effect. The effect on the body of all vitamins without exception is impossible, without the participation of nicotinic acid. The effect on the body of all vitamins without exception is impossible, without the participation of nicotinic acid. With long-term use, nicotinic acid lowers blood cholesterol and reduces the size of soft cholesterol plaques.
The vasodilating effect of nicotinic acid is very pronounced, especially in relation to small vessels and capillaries. This property of nicotinic acid makes it a very valuable means of expanding capillaries. If a person progresses rapidly enough, the growth of his capillary network is delayed by the growth of muscle tissue. Thickening of the muscle fiber 2 times impairs its blood supply 16 (!) Times. Insufficient provision of capillary blood flow can thus become a limiting factor in muscle growth and cause stagnation in all sports results. The use of nicotinic acid in this case helps the athlete out of stagnation.
Nicotinic acid is also good because it has just a powerful tonic effect on the whole organism.
If, for example, a person is prone to colds, then a couple of months of treatment with large doses of Vitamin PP make him immune to external banal effects. Nicotinic acid stimulates the adrenal glands so well (the adrenal glands have nicotinic “receptors” that are stimulated only with nicotinic acid and nothing more) that a single intravenous injection of a large dose of nicotinic acid can break an asthma attack. With long-term treatment with nicotinic acid, hypertrophy of the adrenal glands and an increase in endurance occur. The rate of catabolic reactions is such a "nicotine" hypertrophy of the adrenal glands does not change.
With a sufficiently long use of nicotinic acid in the body (both in the central nervous system and in the periphery), the amount of serotonin increases. Serotonin is both a neurotransmitter and a tissue mediator. In some reactions, it manifests itself as a mediator of the sympathetic nervous system, and in others as a mediator of the parasympathetic. It is one of the good endogenous (internal) growth hormone secretagogues. When a person falls asleep, the blood level of serotonin rises and this is the main reason for the increase in secretion of growth hormone. Serotonin as such strengthens the nervous system well.
Prolonged use of high doses of nicotinic acid increases the energy in general and at the same time makes a person internally calmer and more balanced.
The serotonin content in the CNS can be increased even more by combining nicotinic acid with pyridoxine (Vitamin B6). Pyridoxine is taken orally in tablets up to 300 mg per day.
Large doses of nicotinic acid can (though not immediately) remove a person from nervous depression. As a person who has a certificate from a narcologist, I can quite authoritatively state: slow intravenous administration of 50 ml. nicotinic acid is quite capable of taking a person out of binge drinking, “breaking off” abstinence. Nicotinic acid also helps with heroin breaking, but only in combination with some other means of exposure. The introduction of such large doses of nicotinic acid is made in the conditions of the treatment room. The patient lies on the couch, one hand is connected to the system for intravenous drip of nicotinic acid, and the other hand is wearing a tonometer, which allows you to constantly monitor blood pressure.
Blood pressure under pressure of nicotinic acid is reduced in all people, but to varying degrees. Some take the infusion easily enough. They have to lie on the couch only because the procedure itself lasts long enough. In some people initially prone to hypotension, blood pressure drops so much that they have to administer cordiamine subcutaneously, or other light analeptics. They will not weaken the action of nicotinic acid, but they will not allow pressure to fall below the norm. Too much decrease in blood pressure can cause fainting due to the fact that the brain receives less blood, and therefore oxygen, energy and plastic substrates.
Such a procedure can be performed by a doctor, but most often this is entrusted to a qualified nurse who monitors the patient as red as a cancer because of the strong vasodilatory effect of vitamin PP.
The introduction of large doses of nicotinic acid dramatically increases the acidity of gastric juice and the activity of digestive enzymes. With atrophic gastritis, erosions and ulcers of the gastrointestinal tract, pain in the gastrointestinal tract may occur. For most people, ulcers are hidden (in 70% of cases) and people begin to perceive pain in the abdomen after the administration of nicotinic acid. In fact, nicotinic acid only manifests hidden diseases that have not been felt before. For this property alone she can already say “thank you”.
Pyridoxine, with moderate use, can also slightly increase the acidity of gastric juice, but to such a small extent that it does not threaten any troubles, even ulcers.
More than 30 years ago, American researchers described the ability of nicotinic acid (vitamin PP) to block spontaneous lipolysis. Spontaneous lipolysis is the permanent destruction of the subcutaneous fat with the release of free fatty acids (FFA) and glycerol into the blood. Both FFA and glycerin inhibit the secretion of growth hormone.
The introduction of nicotinic acid almost completely blocks spontaneous lipolysis, “cleans” the blood from FFA and causes a powerful reactive release of HGH. The greatest result is observed with the introduction of nicotinic acid intravenously, although the effect is observed with intramuscular and internal administration. Only 10 mg of nicotinic acid, administered intravenously, can increase the content of growth hormone in the blood by 2 times. In sports practice, doses of up to 250 mg are used intravenously. As a result, a pronounced anabolic effect is observed. In the event that it is necessary to increase the growth of a young athlete, nicotinic acid has an effect no less than the introduction of HGH into the body. Its anabolic effect in large dosages may exceed the effect of anabolic steroids.
The only disadvantage in the use of nicotinic acid is that in this case there is an increase in subcutaneous fat. This is caused just by the blockade of spontaneous lipolysis. This side effect is corrected by diet and "drying", following treatment with vitamin PP.
A very good effect on the somatotropic function of the body has vitamin W or carnitine. He was also called growth vitamin for his ability to enhance the growth of small children. Carnitine increases cell membrane permeability to fatty acids. As a result, fatty acids easily penetrate into the cell, where they are oxidized with the release of large amounts of energy. Carnitine, by the way,
contributes to a more complete oxidation of fatty acids, which under normal conditions is difficult. Reduction of fatty acids in the blood under the action of carnitine leads to increased secretion of HGH by the pituitary gland. In combination with the "energy feed" as a result of a more complete oxidation of fatty acids, this creates the necessary prerequisites for enhancing anabolism.
The only disadvantage of carnitine is that it only affects the young growing organism of children and adolescents, which more gratefully responds to the introduction of carnitine than the organism of adults.
Vitamin K (water-soluble form - vikasol) is able to activate the somatotropic function of the pituitary gland. In a young growing body, vitamin K can even cause the reproduction of eosinophilic pituitary cells and a subsequent steady increase in HGH secretion.
We just need to remember that vikasol can accumulate in the body. Therefore, you need to take vikasol course of 5 days followed by 3-day breaks. Vikasol treats low blood clotting, and in this case it is unnecessary to worsen the capillary circulation. Therefore, overdose vikasol in no case be impossible. Vikasol is available in tablets of 15 mg. The highest daily dose of the drug is 30 mg.
There are several different forms of vitamin K, but only one of them is water soluble. It was she who got the name Vicasola (Vitamin K3).
Of vitamin-like substances deserves attention Mildronate. Apply it as a reducing agent after heavy physical exertion, however, it is able to reduce the level of FFA in the blood and, thereby, slightly increase the secretion of HGH.
In general, all crystalline amino acids, arranged in tablets, or enclosed in capsules, can to some extent increase the release of somatotropic hormone into the blood. For this, naturally, an optimal balance of both essential and non-essential amino acids is necessary.
However, there are separate amino acids that can increase the level of somatotropin in the blood many times. But they are good to use for this in mega doses (ultra-high doses). Palm holds here arginine.
Arginine is a replaceable amino acid. With intravenous drip in a dose of 0.5 g per 1 kg of weight increases the content of somatotropin in the blood at least 2-3 times. The same dose taken orally acts much weaker.
Initially, intravenous arginine was used only as a test. The reactive release of somatotropin was judged on the safety of the reserve capabilities of the pituitary gland, i.e. concluded that it is worthwhile to inject HGH from the outside, if the own capabilities of the pituitary to produce somatotropin are large enough and need only adequate stimulation.
In simple terms: if the level of HGH after the introduction of arginine is slightly increased, then the pituitary is not able to produce the right amount of its own HGH and somatotropin must be introduced into the body from the outside, otherwise the desired result is not obtained. If the body "gives out" a strong reaction, then with the pituitary gland everything is in order. It "works" and to enhance, say, anabolism, you can completely do without injections of expensive HGH. You only need to make your own pituitary gland (or rather, eosinophilic cells of the anterior pituitary gland).
Since we are already talking about the assessment of reserve capacity, it will not be superfluous to know that the same tests are made with other drugs already known to us: insulin and L-DOPA. Insulin is administered intravenously in an amount of 0.1 U / kg. Normally, the amount of HGH in the blood should increase by 2-3 times compared with the original background. When the L-DOPA test is carried out, the drug is taken orally on an empty stomach. The content of HGH in the blood of men is increased not less than 3 times, and in women not less than 2 times (up to 20 mg / ml 3 hours after drug administration). In individuals, the HGH content in the blood may increase to 60 ng / ml, but this is already a rarity.
There are also tests with glucagon, propranolol and some other drugs. To find out how much carbohydrate food suppresses the secretion of HGH in a given person, a glucose suppression test is performed. In the morning, 100 g of glucose is given to a person on an empty stomach, and then it is determined how much the level of HGH in the blood has decreased.
The maximum decrease in its level should occur in 2 hours. And the amount of HGH in the blood should not fall below 2 ng / ml. If it falls below, you need to significantly revise your carbohydrate diet in the direction of its reduction, or look for
a serious pathology of exchange (and it’s better that both together). With acromegaly, diabetes, renal failure, and some other serious chronic diseases, a paradoxical increase in plasma HGH levels in response to glucose load occurs.
Let's return, however, to amino acids. Having started his “career” with diagnostic tests, arginine “entered” into the market of sports nutrition products both in pure form and as part of supplements. The only problem is that when taken orally, arginine is much less effective than with intravenous administration. In order to somehow activate the release of HGH by the pituitary gland, it is necessary to “eat” at least 30 g of pure arginine on an empty stomach. Something I did not meet in the market of sports nutrition products, whose form of release would allow to use at the same time such amount of arginine.
Using small doses is just a waste of time and money. There are products that must either be applied as it should, or not applied at all.
Let us now recall the chain of catecholamine synthesis from phenylalanine (or from the amino acid tyrosine).
Note: L-DOPA can be synthesized in the body directly from phenylalanine, bypassing the tyrosine stage. It is L-DOPA that is now the main object of our attention as a substance capable of increasing the post-training release of somatotropin.
Nature arranged the body very wisely, with multiple safety net. If, due to lack of nutrition in the body, the essential phenylalanine acid is not enough, it (the body) begins to synthesize L-DOPA from the essential amino acid tyrosine. There will never be a large deficiency of tyrosine in the body, for we know that any replaceable amino acid can be synthesized from glutamic or aspartic acid.
Acceptance of pure tyrosine immediately significantly increases the content of L-DOPA in the CNS. At the same time, even the user's subjective sensations coincide to a certain extent with the subjective sensations of the person taking L-DOPA. Acceptance of at least 2 g of tyrosine (on an empty stomach) causes a feeling of slight relaxation and calm. Almost the same feels the person taking the L-DOPA, which is considered (and is) the backup link of the sympathetic-adrenal system.
The more central nervous system contains L-DOPA, the more stable the nervous system, the less it can be depleted.
By itself, the administration of tyrosine does not affect the synthesis of HGH or its secretion in any way. However, the strengthening of the reserve link of the CNS and the increase in the amount of L-DOPA synthesized from tyrosine lead to the fact that the training and post-training secretion of growth hormone increase significantly.
L-DOPA is synthesized from tyrosine in the liver by the action of the enzyme tyrosinase. 2 points are crucial here. The first point is that the liver is, if not perfect, then at least relatively healthy, otherwise tyrosinase will work poorly. The second point is that tyrosinase is activated by copper ions. In principle, it doesn't matter where a person gets copper from: strawberries or vitamin-mineral complexes. However, the second way seems to me faster and easier, especially since copper there is in the already “finished”, ionized form.
Reception of tyrosine favorably differs from L-DOPA in that it does not give any side effects and is not toxic. It would not hurt any athlete to have tyrosine in his home medicine cabinet as a light sedative. We are surrounded by stress. Nobody is insured against worries and negative emotions. Why tolerate them if you can just take a little tyrosine. And the nerves will be fine and the training results will increase.
Even if we discard the direct effect of tyrosine on the somatotropin system, tyrosine can be used simply as a reducing agent after large-scale training loads. From the point of view of biorhythmology, tyrosine is best taken in the evening or in the afternoon.
Looking again at the scheme, we can see that not only dopamine is synthesized from L-DOPA, but also melanin, a special kind of pigment that is responsible for coloring hair, eye iris, skin, etc. If there is a shortage of L-DOPA in the body, melanin is partially spent on the restoration of the reserve link of the central nervous system. For this reason, even children of seven years old can become gray after strong stress. Often, age graying hair is associated with an age deficiency of L-DOPA. One very witty experimenter proved that graying hair can be easily cured by taking large doses of tyrosine.
However, shouting "Hurray!" In this regard is still early. Doses of tyrosine were not just big, but monstrous, 1 g per 1 kg of body weight. This once again proves the absence of tyrosine toxicity.
The point is, in general, not gray hair. Hair is cheaper and easier to paint over than tyrosine instead of regular food. Gray hair is an indirect indicator of aging of the nervous system and the same indirect indicator of the weakening of the somatotropin system. Therefore, even in small quantities, tyrosine will be useful as a means of delaying the aging of the central nervous system.
And now, let's remember that at the beginning of the whole chain is phenylalanine - an essential amino acid. Reception of phenylalanine also activates the entire chain of catecholamine synthesis. After all, L-DOPA can be directly synthesized from phenylalanine. Numerous experiments have shown that there are some differences.
whether catecholamines are synthesized directly from phenylalanine or through the tyrosine formation stage.
In biochemistry, this happens often: the same biological chain can produce a different end result depending on at what stage the mechanism itself was launched. First, the intake of phenylalanine does not cause relaxation and sedative effect on the central nervous system. Quite the contrary, taking several grams of this amino acid helps to feel a surge of energy, reduces overall lethargy, lethargy and apathy. Secondly, although phenylalanine increases the content in the reserve L-DOPA unit, this L-DOPA does not lead to an increase in the amount of pigment.
Like tyrosine, phenylalanine taken outside of training on the somatotropin system does not act in any way.
However, in the period of active training, it allows you to achieve a significant increase in the release of somatotropin, both during training and during the training period.
In the market of sports nutrition products, the amino acid ornithine is actively promoted as a means of stimulating the release of somatotropin into the blood. However, scientific data that would confirm the correctness of these recommendations are not yet available. And you can advertise anything.
The topic of amino acid stimulants of education and secretion of HGH, I think, is one of the most promising areas of sports pharmacology. After all, HGH is a peptide consisting of amino acids and why increase its formation if not amino acids. Amino acids respond well to various modifications, and I think there are still a lot of surprises ahead of us.
Exercise is undoubtedly the strongest stimulator of HGH secretion. Under the influence of intensive training, the peaks of HGH emission during the day become more frequent and amplified in amplitude. When building a training plan, it is necessary to take into account the interaction of HGH with other hormones during a workout. The higher the training intensity, the greater the release of HGH. The ejection force may increase during the first half hour of the workout, after which it somewhat decreases. At the same time, the release of sex hormones and thyroid hormones increases, which potentiates the effect of HGH on tissue.
The release in the blood of catecholamines, especially norepinephrine and adrenaline. This is the first phase of training stress, aimed at mobilizing the body’s energy resources. It has already been said that HGH is an adaptive, "stressful" hormone. Insulin secretion is somewhat reduced, and this has its own explanation. HGH, sex hormones and catecholamines are contra-insular factors that weaken both insulin release and its effect on tissue, otherwise insulin blocks the mobilization of energy resources HGH together with catecholamines and thyroid hormones primarily break down liver glycogen, which is broken down into glucose and utilized by muscles .
Muscle, oddly enough, can not utilize glucose from the blood. Glucose coming from the bloodstream, they first turn into glycogen, and then disposed of. When glycogen stores in the liver run out of HGH, the catecholamines and thyroid hormones “pounce” on adipose tissue. First, subcutaneous, and then internal. Fatty acids infest blood, but are not properly utilized. This requires glucose, and there is no cash supply of glucose. Muscle glycogen (for some reason no one knows this) cannot turn into glucose and in this case can “not do anything” for the utilization of fatty acids.
After 20 minutes of training (for beginners), blood plasma albumin in the liver turns into glucose, and this newly formed glucose helps to quickly utilize fatty acids. Highly trained athletes plasma blood proteins are utilized for energy needs not after 20, but after 10 minutes of training. The athletes of the workshop qualification process "gluconeogenesis", i.e. Neoplasms of glucose in the liver are extremely well developed.
They almost from the first minutes of training glucose in the liver is formed from fatty acids and glycerin. And this glucose of fatty origin helps muscles utilize fatty acids and glycerin, which are completely oxidized to form energy stored in the form of ATP. 0.5 hour workout level
HGH in the blood begins to decline smoothly. At the same time, the level of thyroid hormones and catecholamines falls. However, the level of glucocorticoid hormones, which inhibit the effects of HGH, thyroxin and sex hormones, increases. This is due to the fact that adrenaline stimulates the peripheral serotonergic structures of the body (nerve cells that produce serotonin in the periphery), serotonin begins to stimulate the adrenal cortex and a large amount of glucocorticoid hormones are released into the blood.
Glucocorticoids further enhance liver gluconeogenesis. Insulin secretion remains suppressed. The second phase of training stress comes, which is characterized by a significant increase in catabolism. This increase in catabolism is caused by the fact that glucocorticoid hormones spend mainly alanine on the needs of gluconeogenesis, an amino acid that they take from muscles. This just leads to the development of catabolic processes in muscle tissue.
After 1 hour after the start of training, there is already a significant predominance of catabolic processes over anabolic processes. How to solve the problem? How to prevent muscle catabolism? The conclusion suggests itself: training should be short enough to achieve energy deficiency in muscle tissue and the synthesis of glucose from fatty acids and glycerol.
If the training lasts longer than necessary, alanine will go to the body’s energy needs and then muscle catabolism is inevitable.
Ignorant people who do not even know the basics of normal physiology in popular magazines write that it is necessary to “bomb” every muscle for hours to cause muscle catabolism. And the more muscle catabolism, the more, according to their claims, muscle anabolism develops during the rest period.
Any more or less serious academic from the academic community will tell you that muscle hypertrophy develops solely as a response to energy shortages and nothing more. If the muscle works too long, then catabolism of muscle tissue develops. Muscular hypertrophy is out of the question. On the contrary, the muscle begins to "dry out."
In the light of the above, it becomes clear why at present the global trend is to shorten training with a simultaneous increase in their intensity. In order to gain the necessary total amount of training loads, short workouts are often carried out: 2-3 times a day, and sometimes even more often. Now athletes who train 3 times a day for 20 minutes do not surprise anyone.
The intensity of training begins to take unprecedented forms. Some athletes conduct short high-intensity workouts without a break between sets. How it's done? I will give a simple example. The athlete comes to the gym and begins to do a three-set: squats, deadlift, bench press. Such a set is made as follows. Warm-up approach in squats, then immediately without a break (!) Warm-up approach in the harness and immediately without a break, warm-up approach in the bench press. Then everything repeats again. Warm-up approaches alternate and the main ones begin. The main approach to the legs, then without a break, the main approach in the deadlift, then without a break, the main approach in the bench press. And so the whole workout.
In terms of intensity, such training is approaching a sprint. Pot pours in 3 streams. After each approach in the bench press, you have to wipe the bench with a special towel. It is not easy to be drawn into such a high intensity, but one cannot do without it. First, in the first 0.5 hours of training, the release of HGH into the blood (in quantitative terms) is directly proportional to the intensity. The higher the intensity, the greater the ejection. And, secondly, without such a high intensity, it is impossible to complete the required number of exercises (approaches, repetitions) in 20-30 minutes.
When in the mid-60s of the twentieth century. developed the basic concept of muscle growth, it turned out that the growth of muscle mass is directly proportional to the dependence on the amount of work done during the workout. The time frame of training is not limited. In the 70s, an additional criterion appeared - training time. Now, muscle growth has become directly proportional to the amount of perfect muscle work and is inversely proportional to the unit of time for which the work was performed.
With equal volumes of muscular work, the maximum muscle growth was where this amount of work was performed in the minimum amount of time.
When high-intensity workouts began to come into vogue, a wave of indulgence in stimulants began, right up to amphetamine-type stimulants. Without stimulants, short high-intensity workouts seemed all impossible.
In order not to deplete the nervous system, stimulants were combined with some steroids that have a greater affinity for nervous tissue than others. Payback was not long in coming. Heart attacks and acquired heart defects began. Who had time to replace the heart valve, he was alive, who do not
managed, that is not. People have become more cautious. Instead of stimulants, they began to use reducing agents, economizers, and energizers, nootropes.
They allowed to perform a huge amount of work in a short time with less stress on the heart muscle. The heart began to train separately - and this immediately gave its result. Athletes reached a new, unprecedented level. Sprint running gained unprecedented popularity among the “siloviki” and bodybuilders.
2. Sleep is an important factor in the proper secretion of HGH. In the process of evolution, the mechanism of energy saving and energy supply of the body during sleep was very clearly worked out. As soon as a person falls asleep, the level of HGH in the blood immediately rises, especially during the first 2 hours of sleep. One of the main functions of HGH is fat mobilizing. During sleep, a person does not eat, and the body includes a food supply route - fat. If during the day of wakefulness the body eats carbohydrates and amino acids, then during sleep it is mainly fatty acids.
Cleavage of subcutaneous adipose tissue and the release of FFA and triglycerides into the blood is provided by somatotropin. Naturally, catabolic slows down and anabolic processes in the body increase. Catabolic processes during sleep increase only in relation to adipose tissue.
At the slightest sleep deficit, the secretion of somatotropin is immediately impaired.
With improved sleep, on the contrary, is restored. The recommendation to sleep at least 2 times a day has a serious physiological rationale. Fractional sleep leads to a marked increase in secretion of HGH. If a person sleeps at night and at least 1-2 hours a day, then the total duration of daily sleep does not change, however, the secretion of HGH improves markedly. An even better effect is observed if a person sleeps 3 times a day.
The main sleep is at night, and during the day 2 sleep for 1 hour. The total duration of daily sleep at the same time remains unchanged. In the presence of 2 breaks for daytime sleep, the duration of night sleep is significantly shortened.
The ideal option is a combination of 3-fold short workouts with 3-fold daily sleep. Small children sleep 3-5 times (sometimes more) per day. In many respects due to this, their level of somatotropin is very high, and anabolism significantly prevails over catabolism.
Daytime sleep allows you to increase the release of HGH. This also increases the release into the blood of sex hormones that have an anabolic effect, decreases the release of glucocorticoids, showing a catabolic effect. In general, a more favorable background is created for the reaction of the anabolic action of somatotropin. With age, the duration of sleep is significantly reduced and its depth decreases. In parallel with this, somatotropin secretion is also reduced. Do I have to say how negatively it affects the joint-ligament apparatus, and also on the general level of health in general.
In sports practice is widely used such procedure as "electric." "Electro" is a device that supplies pulsed rectangular currents of constant voltage. One electrode is superimposed on the back of the head, and the other on the closed eyes. When you turn on the device and the correct selection of characteristics, the patient falls asleep and sleeps until the device turns off. In this procedure, the current through the eye nerves goes straight to the hypothalamus, to the center of sleep, after which the person falls asleep. Electrosleep is usually used in the treatment of fatigue, but it can also serve as a good alternative to daytime sleep if falling asleep during the day is difficult for some reason.
With the aid of the electrosleep apparatus, even electroarcosis can be triggered - a dream of such a depth that allows for surgical intervention.
Apparatus for electrosleep and elektronarkoza unfairly rarely used in clinical and sports practice. They are able to replace many drugs, and it will be very difficult to count them as doping.
With the aid of an electrosignic apparatus, it is possible to inject drugs directly into the brain, which have hypnotic, sedative, regenerating or antihypoxic effects. This is done very simply: the orbital pad is moistened with a solution of the necessary medication and applied to the eyes. When current is switched on, the medicinal substance penetrates into that portion of the midbrain (hypothalamus where sleep is formed) through the ocular neurovascular bundles, i.e. to the center of sleep.
This method of administering drugs has several advantages over internal administration or injecting: 1. Medicinal substances do not irritate the gastrointestinal tract and do not penetrate into the liver; 2. Medicinal substances do not enter the general bloodstream and cannot be detected using conventional tests. This may be important in cases where the drug is classified as doping and detecting it in
body undesirable; 3. Drugs selectively accumulate in the brain tissue; 4. The consumption of medicine is reduced by tens, and even hundreds of times.
If during internal reception no more than 2% of the amount of the drug taken in penetrates into the brain, then during electrophoresis the amount of the drug penetrating the brain tissue is an order of magnitude more; 5. The quality of the action of the drug is not past biotransformation in the liver can be much better than after the injection, and even more so the internal reception.
To carry out the electrosign procedure, low-frequency impulse currents of 1-150 Hz, duration 0.4-0.2 ms, voltage up to 50 V and amplitude 4-8 mA are used. In physiotherapeutic practice, special devices are used: “Electrosloon-1”, “Electrosloon-2”, “Electrosloon-3”, “Electrosloon-TH”. Electronarcon and Lenar are used for electroarcosis. Devices for elektronarkoz differs from electrosleep devices in that they use a high frequency of current. In some countries (USA), electrosleep devices are not used at all because of their low efficiency.
Apply only devices for elektronarkoz. If during the procedure of electrosine a slight nap or, at best, superficial sleep develops, then during the procedure of electron scrolling, the patient immediately falls into a deep sleep.
In our country, in Russia, the Elektroson-ChT device is the most popular, which allows us to carry out electrosounder procedures simultaneously for 4 patients.
With the help of this device, in a short time, an entire sports team can undergo an electrosine procedure.
Sometimes, in order to induce daytime sleep, light hypnotics or tranquilizers are used. Only this should be done very carefully, so as not to cause addiction.
Here, benzodiazepine tranquilizers are the most suitable, which have virtually no toxicity. First of all, it is nitrazepam (German equivalent - Radeorm).
This drug is good because it does not cause disturbances in the structure of sleep, does not change the ratio of its fast and slow phases. Sibazon can be put in the second place in the degree of decrease in consumer qualities (the German equivalent is Seduxen, the Polish equivalent is Relanium). Then you can put such benzodiazepine.
derivatives such as alprazalam, phenazepam, nozepam (the Polish analogue is tazepam), lorazepam, bromazepam, gidazepam, clobazam, etc.
Doses should be selected very carefully, empirically. If the action? tablets, for example, is enough, then you should not take the entire tablet at once.
The antihypoxant "sodium oxybutyrate" in small doses up to 2 g, has a calming effect, and in large (4 g) hypnotic effects. Sodium oxybutyrate is a good reducing agent and, most importantly, it significantly increases the plasma HGH content.
Amino acid compounds "Phenibut" was synthesized by attaching a phenyl radical to L-aminobutyric acid. Phenibut according to the classification refers to the "Nootropics", means to improve thinking. But in doses of 2 to 4 g, it has a short-term hypnotic effect. Phenibut is good because it increases the content of dopamine in the CNS, and therefore increases the training and post-training increase in the level of somatotropin in the blood plasma.
All of the above drugs can be injected directly into the brain, not only with the aid of the electrosignic apparatus, but also with the aid of the apparatus for ordinary electrophoresis. The procedure in this case is called "transcerebral electrophoresis". Apparatus for conventional electrophoresis is injected into the body of the medicinal substance using conventional direct current. This direct current is obtained by rectifying normal alternating current from our electrical grid. There are two main methods of transcerebral electrophoresis: transorbital and intranasal. When working on the transorbital technique, one forked electrode is placed on the orbits and the other on the occipital region, capturing the upper cervical vertebrae.
When working on the endonasal technique, one forked electrode is inserted into the patient's nostrils, and the other is applied to the back of the head, as in the case of transorbital electrophoresis. If during transorbital electrophoresis, the medicinal substance is absorbed into the brain through the orbital neurovascular bundles, and during intranasal through the neurovascular bundles of the nose.
The most widespread transorbital technique. To date, private methods have been developed for the introduction of sodium oxybutyrate and all benzodiazepine tranquilizers through the orbit (from the anode). Although the introduction of vitamin B1 and glutamic acid is made only by endonasal technique.
The procedure is performed using a conventional electrophoresis apparatus. The applied current is calculated in mA. The current density in conventional medicinal electrophoresis usually ranges from 0.01-0.1 nA / m2.
The duration of the procedures ranges from 10 to 40 minutes. Serving as a source of direct current wall-mounted apparatus: AGN-1, AGN-2, AGN-32, portable AGP-33, AGVK-1. In these devices, the voltage of the sinusoidal mains current decreases to 60 V, after which the current is rectified and smoothed. The current is controlled by a milliammeter.
Athletes who actively combine work with workouts sometimes do not have the opportunity not to sleep during the day, but even sit down to rest.
In this case, there is only one way out: to modify night sleep in such a way as to enhance its restorative, anabolic and anti-catabolic effect. There is a method of influence called “extended physiological sleep”. It is based on taking a sleeping pill a few hours before bedtime. Night sleep, therefore, is extended by 2-3 hours. Many hypnotics, and in particular, barbituric acid derivatives, have the ability to increase the secretion of growth hormone by night.
The most common hypnotic drug barbiturate series - Phenobarbital. Previously, he was widely known under the name "Luminal". In addition to it, derivatives of barbiturate acid are also used, such as, for example, Cyclobarbital, etc. There are features that distinguish them from sleeping pills of other groups. Barbiturates, in particular, somewhat inhibit the activity of the adrenal cortex and the release of catabolic hormones - glucocorticoids. In this regard, they can be regarded as drugs with anti-catabolic effects, although in this case it is the main one.
The hormones of the adrenal cortex are antagonistic relationship with sex hormones - androgens. The use of barbiturates leads to increased synthesis of androgens by the sex glands. Sometimes the effect reaches such an extent that people who use barbiturates for a long time for some chronic disease (epilepsy) become overgrown with body hair like monkeys.
But the main thing is that by reducing the synthesis and release of glucocorticoids into the blood, barbiturates “disinfect” the secretion of HGH by the pituitary and eliminate the block of HGH exposure to peripheral tissues (in this case, the liver, where somatomedin is produced).
If we use barbiturates to prolong a night’s sleep, utmost care should be taken. Barbiturates have the ability to accumulate (cumulate) in the body. Therefore, they can be used for no more than 10 days in a row and in minimal doses. Benzodiazepine derivatives are less toxic, or rather not toxic at all. Though they are ranked as tranquilizers. Their tranquilizing effect is sometimes (depending on the dose) so much that it causes sleep. They are quite suitable for use as a sleeping pill. Sodium oxybutyrate and phenibut are still more preferred as they have a regenerating and slightly anabolic effect. Phenibut greatly enhances the synthesis of dopamine in the CNS, and dopamine, as we already know, is a good stimulator of HGH secretion.
In the middle of the twentieth century. The treatment of nervous, mental and somatic diseases with prolonged sleep has been widely practiced throughout the world. Patients slept 10 days in a row, waking up only for eating, using the toilet and taking a new sleeping pill. Conducted such treatment exclusively in stationary conditions. Until now, in our country, in some clinics, a 5-day sleep is used to treat depletion of the nervous system.
It is noteworthy that prolonged sleep manifests maximum efficacy in gastric ulcer and duodenal ulcer, and in fact the most powerful cure for peptic ulcer is somatotropin.
In practical sports medicine, prolonged sleep is simply impossible to apply, but I often had to put into practice 2 days of sleep to treat overtraining and to overcome the "stagnation" in the growth of athletic performance. Such a dream is held at the weekend. In the evening, the athlete goes to bed as usual. In the morning after waking up he takes sleeping pills, has breakfast and falls asleep again until the evening. In the evening he wakes up, takes sleeping pills, dines and goes to bed again until morning. If a person falls asleep on Friday evening, sleeps all Saturday and Sunday (with breaks for eating and a new dose of sleeping pills) and wakes up only on Monday morning, then the duration of such sleep is a total of 2.5 days.
For such a dream, all of the above preparations are suitable, and it is even better to alternate them in order to avoid cumulation and addiction. Benzodiazepine derivatives or their combination with sodium hydroxybutyrate are the most preferred. In the case of such combinations, both benzodiazepines and hydroxybutyrate are taken in moderation.
Food taken during this 2.5 day's sleep should ideally consist of amino acids, proteins and proteins alone. So we will achieve maximum release of somatotropin and an increase in muscle mass will be combined with a decrease in subcutaneous fat.
In no case can antipsychotic drugs such as aminazin etc. be used with a sedative or hypnotic goal. Many years ago, antipsychotics were created to treat riotous mental patients. They have such a strong sedative effect that an ordinary person, taking a certain antipsychotic, falls into a deep sleep. This sleep can last for several days, as some antipsychotics can cause sleep even deeper than potent sleeping pills.
Neuroleptics, however, have a mass of undesirable side effects. The most “bad” trait of neuroleptics is a decrease in the synthesis in the nerve cells of L-DOPA, dopamine, norepinephrine and even the destruction of the nerve cells that produce these neurotransmitters. Sleep under the action of neuroleptics not only leads to increased secretion of somatotropin, but on the contrary, blocks the release of both somatotropin and sex hormones. Anabolic processes in muscle tissue slow down significantly.
But the mass of adipose tissue is constantly growing. Many little knowledgeable doctors prescribe for their patients with hypnotic drugs such drugs that destroy the central nervous system in the truest sense of the word. Therefore, it would be an unforgivable mistake not to focus on this issue. Hypnotic hypnotic strife and this should always be remembered.
Sleep management can be carried out without any drugs at all, having mastered at least elementary relaxation skills. There are many ways and techniques of relaxation.
Let's try to dwell on the most common of them, which is called classic autogenic training by Schulz. Having mastered the skills of such a training, a person can properly immerse himself in a state of deep relaxation or sleep. Even if a person does not manage to fall asleep, and he is just in a state of deep relaxation, this noticeably affects the biological activity of the brain and enhances the secretion of growth hormone.
For complete relaxation, you should lie on your back and apply a standard set of techniques: 1. Close your eyes tightly (it is best to go to a darkened room where total darkness reigns); 2. Imagine the feeling of heaviness: 1) in the hands; 2) in the elbows and forearms; 3) in the hands from the tips of the fingers to the shoulders; 4) in the legs, starting from the tips of the fingers and ending with the hip joints; 5) heaviness in the gluteal muscles; 6) heaviness in the back muscles; 7) heaviness in the abdominal muscles and lateral abdominal muscles; 8) heaviness in the chest muscles; 9) heaviness in the shoulder muscles; 9) heaviness in the muscles of the neck; 10) heaviness in all muscles of the head.
The latter is the most important task, as relaxation of mimic, masticatory and speech muscles causes the most general relaxation and a feeling of peace. Alternately, a feeling of heaviness is caused: a) in the masticatory muscles; b) in speech muscles (muscles of the tongue and larynx); c) in mimic muscles (muscles of the lips, eyes, eyebrows, forehead). Then, after being able to imagine the heaviness in all the muscles, there comes a feeling of general rest and mild drowsiness.
The third standard technique is the evoking sensation of heat in all muscles. The representation of heat is invoked in the same sequence as the representation of gravity.
If the usual, figurative representation of heat and gravity does not work, it is necessary to use formulas of self-suggestion like: “Hands become heavy and hot,” etc. These formulas need to be pronounced. If the pronunciation of the formulas does not work, you can ask for help from a qualified psychotherapist, having previously checked that he has a diploma. The psychotherapist takes on that part of the effort that you need to show yourself engaged in for concentration and relaxation. Therefore, to work under the guidance of a specialist is much easier and simpler than independently.
As you develop relaxation skills with a specialist, you can go to independent work. For some athletes, relaxation skills have been developed to such an extent that they can plunge themselves into a deep sleep in just a few seconds. Moreover, the time of awakening is set in advance and the person wakes up like an alarm clock.
Sometimes, for a more rapid development of the skills of self-suggestion and relaxation, the formulas of auto-suggestion are recorded on a special audio cassette against the background of music and special sound effects - the noise of rain, the murmur of a stream, birds trills, etc.
There is a small percentage of people who cannot relax even with the help of a psychotherapist. And here we come to the aid of combined methods of psychotherapy. Most often resorted to drug therapy.
If you are not able to relax using self-hypnosis, then you can take a small dose of a tranquilizing or hypnotic drug (so small that in itself it is almost not felt, the maximum of sensations is an easy relaxation) and already against this background use all those self-hypnosis techniques which gave no result in pure form. With this combination, the effect can be obtained in almost 100% of cases.
Another combined method of psychotherapy is electro-psychotherapy, when the techniques of self-hypnosis are used against the background of the influence of the Electrosleep apparatus. The most difficult way is electro-narco-psychotherapy. At the same time, suggestion or self-hypnosis is carried out against the background of the introduction of medicinal substances with the help of an electro-electric apparatus, or with the help of transcerebral electrophoresis according to the transorbital technique.
Such drugs as sodium hydroxybutyrate and phenibut are most suitable for electro-drug therapy. They are good because in addition to the calming and muscle relaxant action, in addition to increasing the release of somatotropin into the blood directly during the procedure itself, they also contribute to a greater synthesis of somatotropic hormone in the eosinophilic pituitary cells and dopamine in the brain stem structures that control the release of somatotropic hormone into the blood during and after exercise.
Since HGH increases blood sugar and fatty acids, naturally, a decrease in their blood level will stimulate the release of HGH. Therefore, the highest level of SP in the blood is observed in the process of fasting, when food does not enter the body at all. An increase in blood sugar and fatty acids will, on the contrary, prevent the release of somatotropic hormone. Inhibition of release of somatotropin into the blood after intravenous administration of glucose demonstrates this very clearly.
The recommendation is 6 times a day, and even more often it is not aimed at increasing the daily diet in quantitative terms.
It aims to reduce the level of sugar and FFA in the blood after a single meal. Thus, "food inhibition" of HGH secretion is minimized.
At night, it is recommended either to eat protein foods without fats and carbohydrates, or to take a mixture of crystalline amino acids, so as not to interfere with the night secretion of growth hormone. Ideally, the last meal should be no later than 6 pm, and before going to bed you can take only pure crystalline amino acids and nothing more.
Most protein foods contain a small amount of fat and carbohydrates. Here we come to the aid of the notorious egg whites (without yolks), which are almost perfect protein foods. They are easily digested, because they do not have a cellular structure (I remind you that an egg is one large cell).
Exclusion of yolks from the diet is necessary not because they contain a lot of cholesterol. Lecithin yolks contain even more, and in terms of the development of atherosclerosis are not dangerous. The negative point is the presence in the yolks of a large amount of fatty acids, which inhibit the secretion of HGH. That is why they should be excluded from the diet.
Strange as it may seem at first glance, small doses of carbohydrates taken during the workout (just small ones) not only slow down, but even contribute to stronger secretion of HGH. Therefore, recommendations for taking a small dose of carbohydrate carbohydrate immediately before exercise, as well as every 15 minutes of exercise, are justified. This may be glucose, fructose, maltose or sucrose. Currently, special dry drinks are available that contain easily digestible carbohydrates in a mixture with vitamins and microelements. They are dissolved in water and taken in small fractional doses before and during exercise.
Excess carbohydrates in the diet throughout the day leads to a significant decrease in the secretion of somatotropin. Therefore, carbohydrates, both simple and complex, should be consumed only as needed, avoiding sweets and confectionery.
4. Temperature stimulants anabolism. Staying at high temperatures significantly increases the content of somatotropin in the blood. For example, during a stay in the sauna, the level of HGH in the blood increases by 2-3 times, you only need to correctly use this temperature stimulator. In the sauna, you need to steam every day, little by little - from 5 to 15 minutes. Otherwise, major changes in metabolism will not be achieved. The minimum frequency of visits to the sauna, which gives an anabolic effect - 3 times a week. A weekly, long stay in a sauna with numerous visits in terms of physiology makes no sense. The steam Russian bath in practice showed even greater efficiency than the sauna. Even in Finland, where visiting a sauna is built into a cult, Finns refuse saunas and build Russian baths.
Proper use of higher temperatures leads to increased anabolic processes with simultaneous "burning" of subcutaneous fat. This is a good indication of increased secretion of HGH. When the body overheats, a very interesting phenomenon occurs, which is called "centralization of blood circulation".
Due to the over-stimulation of the sympathetic-adrenaline system and the release into the blood of a huge amount of adrenaline, a very strong narrowing of all peripheral vessels and expansion of the central ones occur. The narrowing of the vessels in the periphery reduces the thermal conductivity of the skin and prevents excessive heat from penetrating to the central organs. The increased combustion of subcutaneous fat is partly due to the strong contraction of not only the skin, but also the subcutaneous vessels, which disrupts blood circulation in the subcutaneous fat.
Neurotransmitters causing centralization of blood circulation are also inducers of somatotropin release. In a steam bath or sauna, when the air temperature is 110 degrees Celsius, the level of somatotropin in the blood can increase 6 (!) Times. Let's not forget that somatotropin is a stress hormone and its release is induced by any kind of serious stress. Somatotropin mobilizes fatty acids from the subcutaneous fat into the blood and converts mitochondria from carbohydrate to fatty foods to increase their viability.
After all, mitochondria in evolutionary terms are the youngest cell formations and suffer primarily. Protects them from destruction of somatotropin. If adrenaline and glucocorticoid hormones in excessive quantities during severe stress can damage cellular structures, then somatotropin - never.
On the contrary, it prevents cell membrane damage that may occur due to an excess of adrenaline and glucocorticoids.
An additional positive effect of the sauna is a gradual decrease in basal metabolism, which slows down catabolic processes in the muscles, while muscles are known to grow by 60% due to slower catabolism, and only 40% due to an increase in anabolism.
The same can be said about such qualities as endurance and the ability to recover after heavy physical exertion. The development of endurance, incl. and power, generally 70% dependent on slowing down catabolism Increasing endurance allows you to use large training loads and, ultimately, strengthen anabolism indirectly. The cornerstone is naturally an increase in the secretion of HGH.
Exposure to low temperatures can also increase anabolism by increasing the secretion of HGH. How does this happen? When the body cools, a protective reaction occurs - a sharp increase in spontaneous lipolysis. Increasing the level of FFA in the blood increases the body temperature due to the separation of oxidation and phosphorus (thermogenic effect).
In the future comes the "go-ahead". After cessation of cold exposure, the level of FFA in the blood decreases and, accordingly, the level of HGH increases. The only drawback is the increase in subcutaneous fat, as is the case with the use of nicotinic acid. Excess subcutaneous fatty tissue is corrected by diet and subsequent "drying".
Cold exposure must be done every day, and the best form is dousing with cold water. Pouring is usually done in a “stepped” way. At first they drench their hands. After adaptation, which may take different times for each person, depending on the state of health and fitness level, the legs are poured, and finally the entire body.
The speed of this stepwise adaptation is strictly individual. Pouring cold water has an advantage over other types of hardening. Contact with cold water is short-lived, and the body does not have time to overcool, in contrast to such types of hardening as cold showers and bathing in cold water. Hypothermia does not occur, however, the response of the neuro-reflex reaction of the body has time to develop, and the release of somatotropin reaches tangible values (sometimes 3-4 times).
This release is of short duration, however, its anabolic effect is very noticeable. Cold hardening in order to build muscle mass was widely used in the training of athletes of all ages and nations (with the exception of those, of course, who did not take a bath at all).
Cold water can even be poured on people who have any chronic inflammatory diseases. Just do it right, I emphasize again, very carefully, in steps. What is stepwise douche? In the first stage, you pour your hands on the elbow. A conventional bucket with cold tap water is best for this purpose.
No one knows in advance how fast you have exactly, adaptation to pouring elbows will come. As soon as you feel that the complete adaptation has come, you can begin to pour your hands all over. The next stage is to pour the feet together with the hands. For many people, the feet are the “weakest” place in terms of resistance to cold and their adaptation to cold water pouring can take quite a long time.
After the adaptation of the feet, the legs are already knee-deep. And only then, as they adapt, the legs are poured all over. It is at this last stage, when the arms and legs become fully accustomed to dousing with cold water, you can go to dousing the entire body.
To protect yourself from a cold or exacerbation of any existing, chronic inflammatory disease, you can start taking ascorbic acid megadoses (10 g / day for 70 kg of body weight) at the next, most “dangerous” hardening stage, or spend a couple of days of “dry” fasting without food and without water. Most still prefer ascorbing.
It is interesting that during cooling, as well as during overheating, a pronounced centralization of blood circulation occurs. Vessels of the skin, subcutaneous fat and intestines are narrowed. But the vessels of the brain, heart, kidneys expand. The blood along with the heat goes from the periphery to the center. The body seeks to preserve the life of the central organs at the expense of peripheral. On the other hand, the strong narrowing of the vessels of peripheral tissues reduces their thermal conductivity and prevents the penetration of cold into the body, as well as the loss of heat by the body.
5. Dosed painful effect. We have already said what a colossal effect b-endorphin has on HGH secretion. No other pharmacological agent can increase the secretion of HGH 30 times, in whatever dose it is applied. Since this drug is currently not available on our market, the only way to use it is to stimulate the body’s own synthesis of b-endorphin.
Currently, several types of endorphins have been isolated and synthesized - a, b, y-endorphins, dinorphin, b-neo-endorphin, a-neo-endorphin. Fragments of endorphins - enkephalins, which have a morphine-like effect - enkephalin, leucine-enkephalin, methionine-enkephalin, were also obtained. Both endorphins and enkephalins are capable of acting on brain receptors (and non-cerebral tissues) that perceive morphine.
But unlike morphine, as mentioned above, they do not have harmful side effects and do not cause addiction.
It is noteworthy that endorphins and enkephalins are formed not only in the central nervous system, but also in the gastrointestinal tract, and their formation depends largely on dietary factors.
The main methods of dosed pain exposure, known today, are:
a) Multi-needle bed. It is made, most often, from silvered radio contacts stuffed into a rubber mat. It can be made from Kuznetsov applicators. By the way, applicators can simply be applied to the body and pressed with a small load, gradually increasing the size of the load.
A gradual increase in the load is produced because with the release of endorphins, the pain sensitivity decreases more and more. With a sufficiently long exposure, a moment may come when a person stops feeling pain at all.
b) The impact of an electric spark discharge. Spark discharge on the surface of the body is served, most often, by the apparatus of D'Arsonval. The power of the spark discharge is adjustable. If earlier for processing by the D’Arsonval apparatus it was necessary to lose time to go to the polyclinic, now everything has changed for the better. Virtually all medical equipment stores sell small portable devices suitable for home use.
The kit with the device includes a set of nozzles for processing different surfaces of the body and internal cavities. There are many portable electrostimulators operating on conventional batteries. They give a spark discharge no worse than the D'Arsonval apparatus. Only here they do not have special attachments that the D’Arsonval apparatus has.
c) Acupuncture. Traditional acupuncture is performed by a specialist at special biologically active points. There are, however, simplified options in the form of processing certain areas of the body with a multi-needle hammer. This procedure can be done even by a non-specialist. There are also special needle rollers that "roll" on certain parts of the body. There are special areas of the body, the processing of which with a multi-needle hammer or the application of a Kuznetsov applicator causes an especially large release of endorphins.
Such a special part of the body is the neck area. The back of the neck, the trapezius muscles - these are the common features of the neck area. When a competent reflexologist treats a collar with a multi-needle hammer, the release of endorphins is so great that all the sensations experienced by a person are similar to those of a person who has been given morphine. First comes the general relaxation. If somewhere there was not very strong pain, then it weakens at first, and then disappears altogether.
The mood gradually increases, I want to laugh for no reason at all. After the end of the session comes a dream. Almost all, as well as after the introduction of morphine.
d) Pain massage. This is a special massage aimed at causing the patient moderate pain.
The usual general massage is also accompanied by the release of endorphins into the blood, especially if it is accompanied by a thorough study of the neck area. The pain may have a subliminal character and feel like normal pressure. Only after exceeding this threshold, the pain is felt as such. A good deep massage causes subthreshold pain, which is perceived as tactile, but results in the release of endorphins into the blood. As the release of endorphins, the pain threshold will increase more and more, so the power of massage techniques can be gradually increased, but the person will not feel the pain.
In the end, causing the patient moderate pain does not bring any harm, but the benefits of such a massage will be significant.
e) Painful effects of plant chemical agents. It is carried out in the form of overlapping of the body with a nettle broom. At the beginning such overlapping is performed very weakly, on the verge of a touch.
Then, gradually, as endorphins are released into the blood, the intensity of overlap increases, because pain sensitivity has become less due to the previous release of endorphins. In the end, a person’s nettles can be whipped with all their might. He will still not feel any pain.
e) Stretching exercises. Exercises are performed in such a way as to cause moderate pain in the joints.
The difficulty of the exercises is not to stretch too much the places that were previously injured. There should be no exercises that squeeze the menisci of the knee. Joint pain should always be moderate and should be caused not so much by compression as by stretching.
g) whipping a broom in the bath. To induce moderate pain, not only birch whisks are used, but also softwood whisks - pine, spruce.
Despite the fact that the largest release of endorphins is observed when exposed to the neck area - the area of the trapezium, delta and back of the neck, the most appropriate is the effect on the entire back, because when exposed to the spine and paravertebral area, a significant amount of norepinephrine is released into the bloodstream, which, as we know, stimulates a-adrenoreceptors and also increases the secretion of growth hormone.
6. Dosed oxygen starvation. A moderate decrease in the oxygen content in the inhaled air causes a noticeable increase in the content of somatotropin in the blood. This is the basis of the mountain-climatic training of athletes, when training is carried out in the conditions of low mountains and middle mountains. The abundance of mountain resorts speaks for itself. The benefits of moderate oxygen deficiency are well known.
It is possible, however, to simulate the conditions of a mountain climate on a plain. This is achieved in different ways:
a) Exercises aimed at holding the breath. There are a lot of such exercises, and they allow, in addition to light oxygen starvation, to achieve some accumulation of carbon dioxide in the tissues, which has an additional training effect. In this respect, exercises to hold breath, performed on the plain, have the advantage over the usual mountain-climatic training. In the mountains, due to the rarefied atmosphere, a compensatory
increase in the depth of respiration and loss (leaching) of carbon dioxide from the body. Bitter dyspnea, strange as it may seem at first glance, is caused not so much by a lack of oxygen in the body, but by a deficiency of carbon dioxide.
b) Special devices that limit the excursion of the chest - elastic corsets, belts, etc.
c) Respiration by gas mixtures with low oxygen content through special stationary devices. As a rule, these are devices for anesthesia in which ordinary air is mixed with an inert gas — nitrogen. Sometimes carbon dioxide is added to this mixture in an amount of not more than 8% of the inhaled mixture.
d) Breathing through special individual hypoxicators. These are portable devices for home use. The depletion of air with oxygen is achieved in different ways.
Some of them work on the principle of return breathing - inhaling and exhaling are carried out in a closed space. Others work on the principle of creating an additional "dead space" - inhale and exhale are made into a tube of a certain diameter and length, folded by a coil (so that it takes up less space). There are other models.
Sometimes individual hypoxicators attach to the body (most often, on a belt or on the back), and training is conducted against the background of breathing through the hypoxicator. Most often, with an individual hypoxicator run on stationary treadmills. Less often - by the stadium.
e) Placement in an individual thermocamera and a thermocabine. In a closed individual chamber or a pressurized cabin, a person inhales and exhales in the same space until the oxygen content decreases to a certain extent and the carbon dioxide content increases. There are cases of the construction of entire stadiums, where a specific oxygen regime was artificially maintained (low mountain or middle mountain mode).
7. Aerobic exercise. The benefits and effects of aerobic exercises are described in sufficient detail in the wide variety of specialized literature. I will only add that the maximum release of HGH into the blood is observed during sprint. It also causes the maximum release of catecholamines in the blood, as well as endorphins. According to my observations, sprinting more improves mood than a long slow run at a uniform pace. The excitation of a-adrenoreceptors during the sprint is maximal, therefore it is the sprint that is used to train athletes in those sports that require building up massive muscles. If you need to recruit a certain amount of perfect work, then this is done by increasing the amount of sprint workout.
As mentioned above, the consumption of somatotropin is increasing worldwide. And they use it not so much for the treatment of dwarfs and athletes, but for the treatment of constitutional short stature. Women experienced in life experience say that every man must have two main factors: growth and salary. Growth, mind you, is put on the first place. In every joke there is a share of jokes. The rest is true.
Parents of small stature want their children to be taller than themselves, because small growth often creates a lot of problems for a person, which are not even necessary to be listed. On the other hand, parents of normal growth want their children to have growth above average in order to achieve certain sports results. This applies to many sports, incl. and gaming. About basketball and volleyball, you can not even mention it. In these sports, the results are almost that directly proportional to growth.
How is the tactic of increasing growth? The growth zones of long tubular bones, on which, in fact, depends on the height of a person, are usually closed between 18 and 26 years. Sometimes growth stops earlier - at 16 or even at 14. The latter, however, is quite rare. Early puberty contributes to the earlier closure of growth zones, since sex hormones promote calcium fixation in cartilage and their ossification. Later puberty, on the contrary, lengthens the period of bone growth in length, because growth zones do not close longer.
There is the concept of "bone age", which may not coincide with the passport. To determine the bone age, an x-ray of the extreme third of the forearm is taken (snapshot of the distal third of the forearm). If the picture shows the neostosten cartilage of the growth zone, then there is still the possibility of bone growth in length. If this growth zone is already ossified, then it means that the others are also ossified. The discrepancy between the passport and bone ages is sometimes quite significant.
If a 16-year-old teenager has a bone age of 18 years, then this means that he does not have to expect a large increase in height. If at 16 years the bone age corresponds to 13 years (and this happens very often), then the skeleton growth in length will continue for a long time, and the increase in growth will be significant.
In childhood, the child’s growth can be accelerated with the help of a rational sex of vitaminization, against the background of which periodic courses of treatment with carnitine and nicotinic acid are conducted. In adolescence, it is already possible to connect the treatment with somatotropin. The only serious danger to remember is the risk of developing diabetes. In adolescence, it is especially great. In order to assess the possible risk, it is necessary to make a series of special blood and urine tests for sugar with the subsequent construction of the so-called "sugar curve".
In the study of blood sugar should be borne in mind that it can increase with emotional arousal. Therefore, tests are done in the morning immediately after a night's sleep and, of course, on an empty stomach.
The final decision on the absence of susceptibility to diabetes mellitus can only make a specialist after a thorough examination.
Of great importance is genetic predisposition, it is necessary to carefully analyze all the lines of relatives for the presence of diabetes. First of all, you should be wary of a carrier of type 1 diabetes (insulin-dependent diabetes). It is relatively less dangerous to have type 2 diabetes (non-insulin-dependent diabetes, or "obese diabetes") in the family.
If there are no contraindications, you can begin the introduction of growth hormone, but in this case it is also advisable to periodically perform blood tests, determining the sugar curve.
As a young organism grows, under the action of, first of all, sex and, in the second place, thyroid hormones, the skeleton differentiates. Cartilaginous growth zones are gradually narrowed and closed. There comes a complete ossification, and further growth of the skeleton in length becomes impossible.
Anti-androgenic drugs such as flutamide, cyproterone acetate, finasteride, epristeride, and permixon are used to slow the differentiation of the skeleton and close the growth zones in the male body. Only they should be used extremely carefully under the constant supervision of an experienced specialist, and even better, the initial course of treatment should be carried out in stationary conditions.
Growth hormone in itself does not accelerate skeletal differentiation and does not lead to premature closure of growth zones.
Somatotropin treatment can be carried out for a long time, for years, until the differentiation of the skeleton is completed, and the growth zones are closed. You can enter it daily or every other day. Some researchers recommend that during the growth period of an organism, somatotropin is administered 1 time in 3 days in order not to cause significant addiction and the formation of antibodies to the drug.
Small doses of insulin (within 4–14 IU, depending on body weight) enhance the effect of HGH on tissue.
For the fullest realization of the action of somatotropin, administered from the outside, it is necessary to strictly observe all the above conditions for the use of physical activity, sleep, a rational diet, fortification, temperature factors, metered pain effects and moderate oxygen starvation. Only on a favorable physiological background, pharmacology has its full effect.
The use of HGH in medicine began with the treatment of pituitary nanism or dwarfism. Almost simultaneously, they began to treat constitutional short stature, which, in fact, is only a variant of the norm. Later they began to treat somatotropin mental and sexual developmental delays, diseases that occur in premature babies. Moreover, somatotropin is shown not only with delayed sexual development, but also with accelerated sexual development, when the growth zones of the skeleton close too quickly.
This is done so that the young body “has time” to grow before the growth zones are closed due to excessive production of sex hormones.
Since the positive effect of HGH on the skeleton was found, attempts were made to treat the severe injuries of the locomotor apparatus. It was found that with HGH treatment, all spinal injuries, injuries of large and small joints healed almost 2 times faster.
If bone damage can be cured more quickly with any anabolic factors, then cartilage damage only responds to somatotropin treatment. The affinity (sensitivity) of cartilage tissue to somatotropin was 100 times higher than that of anabolic steroids, adaptogens and insulin. Particularly good results were achieved with a combination of somatotropin with low doses of thyrocalcitonin, a hormone of the thyroid and parathyroid glands, which promotes calcium fixation in the tissues and, first of all, in the bones.
Anabolism of soft tissues, incl. and muscular, it is possible to strengthen more insulin than other agents. Therefore, in severe combined injuries, when the bones, ligaments, cartilage and muscles are damaged, the combination of somatotropin, thyrocalcitonin and small doses of insulin is optimal, which, in addition to everything else, potentiates the effect of somatotropin. Today, thyrocalcitonin is present in the pharmacological market in the form of three drugs:
1. Synthetic calcitonin, similar to human thyrocalcitonin; 2. Miacalcin - synthetic thyrocalcitonin, similar to thyrocalcitonin of salmon. 3. Calcitrin - a drug from the thyroid glands of pigs. All three drugs can be administered subcutaneously, intramuscularly and intranasally by instillation into the nose.
In the treatment of severe injuries, it was noted that HGH reduces the excretion of phosphorus and calcium in the urine, contributing to their fixation in the bones, including and in the tissue of the teeth.
The anabolic effect of HGH has been successfully applied in the treatment of burn disease, when a person dies from massive loss of protein and electrolytes through a burn wound. HGH has proven to be an excellent treatment for ulcers of the stomach and intestines. Under his influence, the bleeding stops, the ulcers heal quickly.
With the help of HGH, it was possible to cure dental diseases that are not amenable to conventional treatment, such as periodontal disease, for example.
Heart failure, liver and kidney diseases, trophic disorders - this is not a complete list of those cases when somatotropin can be successfully applied.
The anabolic effect of somatotropin opened him a wide road to sports medicine. For several decades before being attributed to doping, it has already been widely used in almost all sports. First of all, the use of somatotropin in rehabilitation practice in the treatment of the effects of injuries and surgical interventions deserves attention. The sports age of a person has always been and remains short (except for special cases). Therefore, the time that a highly skilled athlete is losing for the treatment of injuries (both operational and conservative) must be minimized.
On the other hand, the weakest part of the musculoskeletal system is cartilage. Cartilage cells from the age of 16 lose their ability to divide. Cartilage itself never fully recovers from damage. Therefore, each injury of the intervertebral disc, meniscus, cartilage surface of the joint is an injury forever, no matter how sad it is to admit it. Part of the cartilage cells begins to multiply in response to damage (reparative regeneration). However, this does not significantly affect the structure of cartilage, which is 97% represented by extracellular substance.
On the other hand, we know that only somatotropin is able to significantly affect cartilage tissue (100 times stronger than other anabolic agents). Moreover, HGH affects both cells and the extracellular substance simultaneously. This makes it a very valuable treatment and, most importantly, the prevention of sports injuries. Age wear of cartilage is a thing, unfortunately, inevitable. Even if there are no acute injuries of meniscuses, during heavy physical exertion meniscus develops - a violation of the trophism of these intra-articular cartilage.
Against the background of meniscus easier all subsequent injuries occur. Even if there are no acute injuries of the intervertebral discs, osteochondrosis develops with age - a lesion of the intervertebral discs due to the usual gravitational load. Most athletes leave the sport because of injuries long before their full potential is exhausted. To possibly postpone this moment, as well as to prevent the development of the usual age-related pathology, willy-nilly, you have to take care, primarily of cartilage.
As a doctor, I believe that somatotropin should be used as widely as possible, because with its help you can not only build muscle. Somatotropin contributes to the development of endurance, has a good overall energy effect. With somatotropin treatment, recovery from extensive physical exertion is much faster.
Earlier and more widespread use of somatotropin in sports practice will prevent the accumulation of microtraumas, age-related wear of the articular-ligamentous apparatus and, ultimately, will prevent serious injuries.
In both clinical and sports medicine, when treating cartilage damage, the combination of somatotropin with low doses of insulin and thyrocalcitonin is most effective.
With respect to muscle tissue, somatotropin does not show such a strong effect as insulin and anabolic steroids. However, only somatotropin can cause an increase in the number of muscle fibers, while all other anabolic agents cause only hypertrophy of existing fibers, without affecting their number.
Increasing muscle mass while reducing fat, HGH favorably differs from steroids and, moreover, from insulin, which simultaneously with an increase in muscle mass inevitably causes an increase in subcutaneous fat. Periodic courses of treatment with somatotropin are also necessary for strengthening the joint-ligament apparatus.
In those sports that require high stamina, somatotropin is as widely used as in those sports where muscle hypertrophy is required. If we take, for example, athletics in its extreme expression - marathon running, then somatotropin is used very widely.
It contributes to hypertrophy of the heart muscle, protects intervertebral discs, menisci and ligaments from microtrauma. The number of mitochondria inside the cell increases, because under the action of HGH, they are able to independently divide and become larger in size. The mobilization of fatty cells from subcutaneous fat and their utilization for energy needs is enhanced. Increased energy, in turn, has a positive effect on protein-synthetic processes.
In spite of the fact that somatotropin and somatomedin C are referred to doping, it is impossible to determine their increased content in the body. The half-life of HGH, introduced into the body from the outside, in a healthy person is only 20-30 minutes. The increased content of somatomedin C is determined for no more than a day. Considering that the content of HGH and somatomedin C in the body can fluctuate widely throughout the day depending on stress, physical exertion, etc. the determination of the HGH and IGF-1 athlete in the body on the eve of the competition, as well as before and after the competition, is highly questionable.
Methods for determining the blood levels of HGH and IGF-1 are of more interest, not as doping tests, but as an assessment of the athlete’s basic and reserve capabilities. Thus, it is possible to determine whether a given athlete needs the additional administration of HGH. If the basic secretion and secretion to the load (provocative texts) are high enough, then it makes sense
to pay attention not to the somatotropic function of the pituitary gland, but to any other parts of the exchange.
1. Immunological methods for the determination of HGH are based on the detection of antibodies to somatotropin in human blood. This is done using:
braking reactions of passive hemaghotinization;
complement fixation reactions;
In many countries, standard kits for determining hormones (including HGH) in biological fluids are available.
In practice, immunological methods for the determination of HGH did not justify the hopes placed on them. And there are several reasons for this. First, against the background of HGH treatment, a small amount of antibodies is produced to it, and after discontinuation of treatment they quickly disappear from the blood. Secondly, the portion of the hormone molecule that binds to the antibody and the portion of the hormone molecule that exhibits anabolic activity, do not coincide in their location in the molecule. For these reasons, immunological methods can determine no more than 10% of the HGH present in the body.
2. Biological methods for determining HGH are based on measuring the biological effects that are caused by HGH. The main ones are:
The test for weight gain in normal rats.
The test of weight gain in dwarf mice.
Test the increase in the length of the tail in hypophysectomized rats.
Tibia test (the effect of HGH on increasing the width of bone cartilage).
Method of stimulating the activity of the enzyme ornithine decarboxylase of the liver.
Methods of stimulating sugar transport in an isolated diaphragm in hypophysectomized rats.
Test the effect of HGH on blood urea.
Test the effect of HGH on fat cells.
Test stimulating the incorporation of radioactive sulfate into cartilage.
The test stimulate the incorporation of uridine into thymocyte RNA.
The test stimulates the incorporation of radioactive proline into procollagen of the skin.
Biological methods have proven themselves well in scientific studies, but with all their accuracy they are unacceptable for determining the amount of HGH in the blood as a doping test.
Once again I will briefly list the group of stimulation tests for the stimulation of HGH secretion, which are used to assess the reserve capacity of the pituitary gland:
Test with insulin. Increased secretion of HGH in response to insulin hypoglycemia is determined. With the introduction of insulin in / in a dose of 0.1 u / kg. With a decrease in glucose level by 50%, the amount of HGH in the blood increases by 2-3 times.
Test with arginine. Arginine is administered intravenously at a dose of 0.5 g / kg for 30 minutes. Normally, the amount of HGH increases by 3 times.
Sample with L-DOPA (dopamine precursor). It is entered inside in a dose of 500 mg. The amount of HGH normally increases by 3-4 times.
Test with glucagon. The introduction of glucagon at a dose of 1 mg increases the secretion of HGH 1.5 times. The response to glucagon can be increased by the administration of propranolol (anaprilina).
HGH secretion suppression samples are also used:
Test with glucose. After taking 100 g of glucose, the amount of HGH is reduced by 2-2.5 times compared with the norm.
Test with somatostatin. Based on the synthesis of HGH secretion by synthetic somatostatin.
There is also a group of somatomedin-based tests.
There is such a thing as a “cancerous constitution” or a predisposition to malignant neoplasms. This predisposition is inherited with the exception of very rare cases. People with a predisposition to malignant neoplasms more often than others achieve great results in sports, and for good reason.
First, protein synthesis in the body of such people is more active than in the body of an ordinary person. On the one hand, this is very good and makes it easier to build muscle mass, and on the other hand, tumors also grow much faster than in ordinary people. Secondly, their energy potential is much higher than the energy potential of an ordinary person. Fatty acids are oxidized more easily and better than other people. But this medal has two sides. Some organs of immunity together in order to devour malignant cells begin to feed on small droplets of fat, always present in the blood, or fatty acids.
However, they cease to perform their direct duties - finding and destroying malignant cells.
Sports pharmacology is used by all. And those who have a cancer constitution and those who do not have one. However, those who have a cancer constitution will achieve maximum results in sports, especially if they are related to building muscle.
Thymus of the thymus gland is responsible for tissue (anticancer) immunity. The maximum mass of the thymus has at the time of the birth of the child. Then it starts to decrease gradually and by the age of 40 almost completely disappears. It is at this point that most people begin to grow malignant tumors, which after a few decades grow to fatal sizes.
High-skilled athletes often come to me for advice with the question: “Do I not injure somatotropin, because I had malignant tumors in my family?” Their fears are due to the fact that all the instructions for the use of somatotropin indicate that it is contraindicated in malignant tumors. No one conducted experiments and no somatotropin was administered to cancer patients. It is just a priori that the growth hormone must necessarily increase all the neoplasms of the body, since it has such a strong growth effect. For some reason, no one writes about anabolic steroids and androgens, although their anabolic effect in appropriate dosages may exceed the anabolic effect of somatotropin.
So what's the answer? Can somatotropin be used by athletes with a cancer constitution or not? The answer will be ambiguous.
At a young age (especially up to 30 years), the use of growth hormone is not only not dangerous, but even desirable. HGH is the only compound that
causes hyperplasia (growth and reproduction) of cells of the immune organs. The first is the cells of the thymus gland, which is responsible for antitumor immunity. The more HGH is used at a young age, the larger the human thymus and the later the time comes when malignant cells begin to develop in the body.
No other tool that significantly increases the size of the thymus gland is currently unknown to science.
If a person is already over 40, then there is a possibility that the formation of a malignant tumor has already begun somewhere in the body, since the thymus gland is almost completely destroyed and tissue (antitumor) immunity is weakened. She does not manifest herself soon. The average cancer grows in a person from 20 to 40 years old and is noticeable, becoming already at the last stage of its development. At this age, the use of somatotropin can already be dangerous. It will contribute to the development of a tumor, if it already exists.
Persons who do not have a cancerous constitution, those who have not died of cancer in the family, can use somatotropin as much as they like at any age: both young and old.
For people with a cancer constitution, there is a danger far greater than somatotropin. These are androgens and anabolic steroids. The fact is that androgens, when introduced, cause a very fast (sometimes even within a few weeks) involution of the thymus gland. Anabolic steroids, although to a lesser extent, also have a similar effect.
Even people who do not have a cancer constitution can get cancer after using androgens to build muscle. People who have a cancerous constitution and are “sitting” on the androgens are just suicide bombers who only accelerate their end. And the point here is not in enhancing protein synthesis, but in the destruction of the main organ of our body's immunity - the thymus gland. For these reasons, as a medical practitioner, I am a principled opponent of the use of androgens in order to build muscle.
The use of anabolic steroids should be alternated with the use of growth hormone. Concurrent use of growth hormone and anabolic steroids is also possible.
Some athletes respond to androgens more strongly than steroids and muscle mass on androgens grows faster. However, the price you have to pay for such a rapid increase in muscle mass is too high.
At present, we have a fairly large selection of different pharmacological agents, among which both are stronger than androgens. One of these means - somatotropic hormone in combination with various pharmacological agents.
Everything is being improved. In the market of sports pharmacology, more and more new forms of growth hormone drugs appear. In addition to human, genetic engineering and synthetic, a culture growth hormone appeared, which is obtained on culturally specific media.
Unfortunately, the price of growth hormone drugs is constantly growing and this is not due to any technical or ethical difficulties. This is due solely to the fact that the demand for the drug is growing. Every person who understands the economy a little bit will tell you that the selling price depends solely on the level of demand for the product and nothing more.
Despite the very low cost in production, HGH preparations will constantly increase in price due to the growth in the level of demand for them.
In this situation, it would not hurt to pay attention to the ways of increasing the content of somatotropin in the body, which are not associated with injections of the drug from the outside.
Genetically engineered somatotropin, as well as genetically-injected insulin, is obtained from ordinary Escherichia coli, in the genome of which the gene of somatotropin synthesis was “wired”. This Escherichia coli forms the contents of your intestines and is as compatible as possible with the body.
It has long been processed methods of colonization of the human intestine with a stick that produces insulin. There are already a lot of people in the world who do not inject insulin, but get it from their own intestines. The same has long been done with somatotropin. Intestinal bacilli, from which genetically engineered somatotropin is obtained, may well be populated into the human intestine for any required period and then, if necessary, removed as easily. Just something no one is in a hurry to develop and promote this technique. It is understandable.
People will simply start sharing HGH-producing E. coli with each other, and then all pharmaceutical preparations will become unnecessary. Giant pharmaceutical corporations are not going to suffer losses, and they will do everything in their power to bury this technique forever. However, maybe we are also lucky. Someone in order to compete will throw on the market a cheap bacterial culture that produces HGH.
Another interesting area is the grafting (transplantation) of the embryonic buds of the anterior pituitary with eosinophilic cells.
If normal tissues after transplantation are rejected by the immunity of the person to whom these tissues have been transplanted, the germinal rudiments are not. They take root in the body of the person to whom they were transplanted. Modern transplantation allows you to replant a person if not all, then almost everything. Even the germinal rudiments of teeth are transplanted and milk teeth grow on the site of this transplant.
Were carried out, and to this day, transplants are carried out on embryonic buds of the anterior pituitary gland, which take root, grow in normal sizes, and begin to secrete HGH. It is most convenient, in my opinion, to make such transplants under the skin, since the implanted cells can be removed quite easily from under the skin at the moment when they are no longer needed, or the secreted HGH gene starts producing any side effects.
In animal experiments, transplants of germinal germs from the anterior lobe of the pituitary directly into the hypothalamus were done. After such transplants, the “additional” secretion of somatotropin was maximal compared with transplants to other organs and parts of the body. The disadvantage of such an operation is that then it will simply be impossible to remove tissue from overgrown eosinophilic cells from the hypothalamus.
The embryonic rudiments of various organs are taken from the usual abortion material. So in what, and unfortunately, we never had a shortage in it. Not all embryonic rudiments take root, most of them are absorbed after transplantation. In order to further improve tissue compatibility, she began to transplant embryonic rudiments grown in a test tube. The father or mother of these embryos is a person who needs a transplant. Most of the embryos die in vitro, but some still survive and the embryonic rudiments of their organs dissolve much less frequently after transplantation.
As biotechnology as a science improves, its industry that is concerned with transplanting embryonic buds will develop and I hope so. This direction seems to me extremely promising.
Many thanks to the writing of the article, the materials of the book Y. Bulanov